| The effects of growth hormone treatment on health-related quality of life in children. | |
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MedLine Citation:
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PMID: 16582566 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: The effects of growth hormone deficiency (GHD) on linear growth in children are well documented, but there is less convincing evidence regarding the impact on health-related quality of life (QOL). We examined QOL in children aged 8-16 years with acquired GHD following treatment for malignancy (AGHD) or idiopathic GHD (IGHD) on commencing growth hormone treatment (GHT) over 6 months. We adopted a longitudinal design involving consecutive patients and their families attending clinic over an 18-month period. Mothers and children were invited to complete questionnaires before GHT (T1) and 6 months later (T2). METHODS: Mothers of 22 children (AGHD n = 14; IGHD n = 8) completed standardized measures of child QOL and behaviour. Children completed parallel measures of QOL, short-term memory tasks and fitness either in clinic or at the family home. RESULTS: For children with AGHD, QOL was significantly below population norms at T1 and improved over time. For children diagnosed with IGHD, QOL at T1 was below, but comparable with population norms. QOL improved over time, though not significantly. CONCLUSION: GHT is potentially valuable for improving QOL in children, especially in cases of AGHD. We conclude that benefits of GHT for QOL need to be evaluated independent of different diagnostic groups. |
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Authors:
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L Sheppard; C Eiser; H A Davies; S Carney; S A Clarke; T Urquhart; M J Ryder; A Stoner; N P Wright; G Butler |
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Publication Detail:
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Type: Journal Article Date: 2006-03-30 |
Journal Detail:
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Title: Hormone research Volume: 65 ISSN: 0301-0163 ISO Abbreviation: Horm. Res. Publication Date: 2006 |
Date Detail:
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Created Date: 2006-04-25 Completed Date: 2006-06-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0366126 Medline TA: Horm Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 243-9 Citation Subset: IM |
Affiliation:
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CR-UK Child and Family Health Group, Department of Psychology, University of Sheffield, Sheffield, UK. l.sheppard@sheffield.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Body Constitution Child Female Growth Disorders / drug therapy*, etiology Health Status Indicators Hormone Replacement Therapy Human Growth Hormone / therapeutic use* Humans Leukemia, Lymphoid / complications Male Quality of Life* Questionnaires Recombinant Proteins / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins; 12629-01-5/Human Growth Hormone |
| Comments/Corrections | |
Comment In:
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Horm Res. 2006;65(5):250-2; discussion 252
[PMID:
16582567
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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