| The effects of gonadectomy on sex- and age-typical responses to novelty and ethanol-induced social inhibition in adult male and female Sprague-Dawley rats. | |
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MedLine Citation:
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PMID: 22036699 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sex- and age-typical responses to ethanol and novel stimuli tend to emerge postpubertally, suggesting a potential organizational or activational role for pubertal hormones in these behaviors. To test this possibility, male and female rats were gonadectomized (GX) or received sham gonadectomy (SH) either prepubertally on postnatal day (P) 23 (early) or in adulthood on P70 (late). Animals were tested as adults for response to novelty and, on the following day, challenged with either saline or ethanol (1g/kg) prior to social interaction testing with an unfamiliar partner in a familiar setting under low light conditions. Gonadectomy did not influence ethanol-induced social inhibition in either sex, but instead altered the microstructure of social behavior, with GX animals exhibiting proportionally less time in social investigation and proportionally more time in contact behavior than SH animals, regardless of age of gonadectomy. The early sham surgical manipulation process itself influenced social motivation, with early SH surgery eliminating ethanol-induced decreases in social preference in both sexes. Response to novelty was unaffected by gonadectomy, but was suppressed in early compared to late SH manipulated animals. These results suggest that adult-typical responses to ethanol and novelty-directed behaviors are little influenced by gonadal hormones during puberty or in adulthood. However, the experience of surgical manipulation itself during development exerts behavioral and pharmacological consequences that last into adulthood. |
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Authors:
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Courtney S Vetter-O'Hagen; Linda P Spear |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-10-21 |
Journal Detail:
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Title: Behavioural brain research Volume: 227 ISSN: 1872-7549 ISO Abbreviation: Behav. Brain Res. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2011-12-19 Completed Date: 2012-04-23 Revised Date: 2013-05-23 |
Medline Journal Info:
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Nlm Unique ID: 8004872 Medline TA: Behav Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 224-32 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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Center for Development and Behavioral Neuroscience, Developmental Exposure to Alcohol Research Center, Department of Psychology, Binghamton University, Binghamton, NY 13902-6000, USA. cvetter1@binghamton.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Castration Central Nervous System Depressants / pharmacology* Estradiol / blood Ethanol / pharmacology* Exploratory Behavior / drug effects* Female Inhibition (Psychology)* Male Progesterone / blood Radioimmunoassay Rats Rats, Sprague-Dawley Sex Characteristics* Social Behavior* Testosterone / blood |
| Grant Support | |
ID/Acronym/Agency:
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R01 AA017355-03/AA/NIAAA NIH HHS; R01 AA017355-04/AA/NIAAA NIH HHS; R01-AA017355/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Central Nervous System Depressants; 50-28-2/Estradiol; 57-83-0/Progesterone; 58-22-0/Testosterone; 64-17-5/Ethanol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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