Document Detail

The effects of gonadal irradiation in clinical radiation therapy: a review.
MedLine Citation:
PMID:  766956     Owner:  NLM     Status:  MEDLINE    
Recent improvements in radiation therapy of some malignancies in lower abdominal sites are leading to a prolongation of life in persons of child-bearing age. These successes require an evaluation of the possible undersirable consequences of the unavoidable gonadal irradiation that occurs in these cases. A review of radiobiological data from experimental animal studies and retrospective clinical studies suggests that in most instances human gonadal exposures in both sexes are insufficient to cause permanent sterility, because the exposures are fractionated and the total gonadal dose is much less than 600 rads. As a consequence, return of fertility must be anticipated, and the worrison questions of radiation-induced genetic damage in subsequent pregnancies must be addressed. This review did not substantiate this fear, because no case reports could be found of malformed infants among the progeny of previously irradiated parents. Some experimental studies suggest that radiation-damaged spermatogonia are self-destructive, but any evidence for this phenomenon in the ovary is nonexistent. We suggest that the difference between fact and theory here may be the mathematical result of the interplay of low probability for occurrences and the few patients who until now have survived long enough for study.
C C Lushbaugh; G W Casarett
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Cancer     Volume:  37     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1976 Feb 
Date Detail:
Created Date:  1976-06-02     Completed Date:  1976-06-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1111-25     Citation Subset:  AIM; IM    
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MeSH Terms
Abdominal Neoplasms / radiotherapy*
Age Factors
Chromosome Aberrations
Congenital Abnormalities / etiology
Dose-Response Relationship, Radiation
Gonads / radiation effects*
Hodgkin Disease / radiotherapy
Neoplasms, Radiation-Induced
Oocytes / radiation effects
Ovary / radiation effects
Radiation Injuries*
Radiotherapy Dosage
Spermatogenesis / radiation effects
Spermatogonia / radiation effects
Testis / radiation effects
X-Rays / adverse effects

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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