Document Detail

The effects of glycol methacrylate as a dehydrating agent on the dimensional changes of liver tissue.
MedLine Citation:
PMID:  1373449     Owner:  NLM     Status:  MEDLINE    
The dimensional changes of liver sections during the course of processing with glycol methacrylate (GMA) or with ethanol are described. Tissue processing with ethanol served as a control. During prolonged processing steps (24 h each), linear shrinkage of tissue specimens dehydrated with GMA at room temperature was 13.2%. Subsequent infiltration with GMA resulted in trivial swelling, and polymerization in slight shrinkage (2.3%). In comparison, processing with cold GMA resulted in shrinkage during dehydration (about 10.8%), a slight swelling in pure GMA, followed by shrinkage during polymerization (2.2%). Short routine processing schedules resulted in similar shrinkage/swelling patterns, although precise values differed slightly. In all experiments, ethanolic dehydration resulted in smaller dimensional tissue changes than did GMA dehydration. The dimensional changes of tissue sections during stretching on water, mounting and drying compensated for the major part of the shrinkage manifested during processing.
P O Gerrits; R W Horobin; I Stokroos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of microscopy     Volume:  165     ISSN:  0022-2720     ISO Abbreviation:  J Microsc     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-05-18     Completed Date:  1992-05-18     Revised Date:  2006-08-08    
Medline Journal Info:
Nlm Unique ID:  0204522     Medline TA:  J Microsc     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  273-80     Citation Subset:  IM    
Department of Anatomy, University of Groningen, The Netherlands.
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MeSH Terms
Ethanol / pharmacology
Liver / anatomy & histology,  drug effects*
Methacrylates / pharmacology*
Staining and Labeling
Reg. No./Substance:
0/Methacrylates; 64-17-5/Ethanol; 868-77-9/hydroxyethyl methacrylate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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