Document Detail

The effects of glycerol on vestibular function and the endolymphatic sac after pre-treatment with colchicine.
MedLine Citation:
PMID:  2635547     Owner:  NLM     Status:  MEDLINE    
The endolymphatic sac (ES) is believed to absorb endolymph. Recent studies have suggested that the ES also has a secretory capacity, a function that may be related to the regulation of inner ear fluid volume and pressure. Other studies indicate that hyperosmolar substances, such as glycerol and urea, may initiate a secretion of glycoprotein into the ES. This function was suggested to be related to a regulatory function of the ES by which it can compensate for a decrease in endolymph pressure. In order to investigate this regulatory potential of the ES, the effect of glycerol on the ES was investigated with or without the presence of pharmacological inhibition of glycoprotein secretion through colchicine treatment. Animals treated in such a way showed marked signs of impaired inner ear function, including loss of postural control and loss of Preyer's reflex. Significant ultrastructural changes were noted in the endolymphatic sac suggesting a disturbed secretory activity. The results may indicate that the endolymphatic sac may actively respond to changes in endolymph homeostasis through secretion of macromolecular substances and that alterations in this secretion may lead to functional disturbances of the inner ear.
M Takumida; D Bagger-Sjöbäck; H Rask-Andersen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta oto-laryngologica. Supplementum     Volume:  468     ISSN:  0365-5237     ISO Abbreviation:  Acta Otolaryngol Suppl     Publication Date:  1989  
Date Detail:
Created Date:  1990-06-12     Completed Date:  1990-06-12     Revised Date:  2008-02-13    
Medline Journal Info:
Nlm Unique ID:  0370355     Medline TA:  Acta Otolaryngol Suppl     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  59-63     Citation Subset:  IM    
Department of Otolaryngology, Karolinska Institutet, Karolinska Sjukhuset, Stockholm, Sweden.
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MeSH Terms
Colchicine / administration & dosage*
Endolymph / physiology
Endolymphatic Sac / drug effects*,  secretion,  ultrastructure
Glycerol / pharmacology*
Mice, Inbred Strains
Vestibule, Labyrinth / drug effects*,  physiopathology*
Reg. No./Substance:
56-81-5/Glycerol; 64-86-8/Colchicine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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