Document Detail

The effects of glucocorticoids on feeding behavior in rats.
MedLine Citation:
PMID:  16540130     Owner:  NLM     Status:  MEDLINE    
Glucocorticoids have major effects on food intake, however, the underlying mechanisms are poorly understood. This article highlights data on the changes that occur when glucocorticoids are removed by adrenalectomy, and the effects of central and systemic administered glucocorticoids on feeding behavior in rats. Next, animal data on the interaction of glucocorticoids with insulin on intake of comfort foods are addressed and the hypothesis that glucocorticoids modify feeding behavior, whereas insulin modifies the choice of food is discussed. Finally a view is presented that hormonal and vagal signals generated when (comfort) food is consumed will affect the corticotropin-releasing factor (CRF) brain network important for the response to stress and the regulation of feeding. With a society, where stress is experienced daily and comfort food is found at every street corner, it will be vital to understand the interactions between the systems that react to stress and regulate feeding behavior to fight the obesity epidemic.
Susanne E la Fleur
Publication Detail:
Type:  Journal Article; Review     Date:  2006-03-15
Journal Detail:
Title:  Physiology & behavior     Volume:  89     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-07     Completed Date:  2006-09-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  110-4     Citation Subset:  IM    
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 GC Utrecht, The Netherlands.
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MeSH Terms
Adrenalectomy / methods
Behavior, Animal
Corticotropin-Releasing Hormone / physiology
Eating / drug effects*
Feeding Behavior / drug effects*
Glucocorticoids / pharmacology*
Vagus Nerve / physiology
Reg. No./Substance:
0/Glucocorticoids; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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