Document Detail

The effects of extracellular potassium, ouabain, and prostaglandins on intracellular potassium activity in sheep cardica Purkinje fibers.
MedLine Citation:
PMID:  7192855     Owner:  NLM     Status:  MEDLINE    
(1) Intracellular K activity (aKi) of sheep heart Purkinje fibers was measured using K-selective microelectrodes (liquid ion exchanger). aKi in the resting state with an extracellular K of 4 mmol . l-1 EK was 112.9 +/- 6.1 mmol . l-1 (n = 47) for a membrane potential (VM) of -73.3 +/- 0.9 mV. VM deviated from the calculated potassium equilibrium potential (EK = -93mV). (2) When extracellular K was decreased to 2 mmol . l-1 or increased to 6 and 10 mmol . l-1 EK changed from -114 to -84 and -73 mV, with little change in aKi. (3) aKi and VM significantly decreased after administration of 10(-6) mol . l-1 ouabain. (4) Prostaglandins (PGI2 10-100 micrograms . l-1 and PGE2 0.01-1 microgram . l-1) decreased aKi without greatly changing VM. The differences between VM and EK became smaller. These effects indicate an increase in K permeability and may explain the antiarrhythmic action of prostaglandins.
M Wiederholt; P Danisevskis; L L Hansen; H J Lichey; K D Platsch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  388     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  1980 Nov 
Date Detail:
Created Date:  1981-03-17     Completed Date:  1981-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  169-75     Citation Subset:  IM    
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MeSH Terms
Electric Stimulation
Evoked Potentials / drug effects
Heart Conduction System / metabolism*
Membrane Potentials / drug effects
Ouabain / pharmacology*
Potassium / metabolism,  pharmacology*
Prostaglandins / pharmacology*
Purkinje Fibers / drug effects,  metabolism*
Reg. No./Substance:
0/Prostaglandins; 630-60-4/Ouabain; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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