Document Detail


The effects of exercise withdrawal on mood and inflammatory cytokine responses in humans.
MedLine Citation:
PMID:  21438778     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mechanisms underlying the relationship between exercise and mood are not well understood. This study sought to investigate the role of pro- and anti-inflammatory cytokines and autonomic balance in determining the impact of exercise withdrawal on negative mood. Healthy men and women who regularly exercised (N = 26, mean age = 25.5 years, SD = 4.5 years) were randomised to exercise withdrawal or exercise maintenance for 2 weeks. Protocol adherence was monitored using accelerometers. Inflammatory markers from plasma (interleukin-6, IL-6; tumour necrosis factor-alpha; interleukin-10; and interleukin-1 receptor antagonist), heart-rate variability (HRV) and measures of mood (General Health Questionnaire-28 (GHQ) and the Profile of Mood States (POMS)) were assessed at study entry and at 2-week follow-up. Exercise withdrawal resulted in significant increases in negative mood over time on both the GHQ (p = 0.028) and the POMS (p = 0.005). Following the intervention, IL-6 concentration was lower in the exercise withdrawal than exercise maintenance condition (p = 0.05). No intervention effects were observed for other cytokines or HRV. The mood changes were significantly related to changes in IL-6 concentration (β = - 0.50, p = 0.011), indicating that reduction in IL-6 was related to increased negative mood. Our results are consistent with positive effects of exercise on mental health, but further research on inflammatory pathways is warranted.
Authors:
Lydia Poole; Mark Hamer; Andrew J Wawrzyniak; Andrew Steptoe
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2011-03-27
Journal Detail:
Title:  Stress (Amsterdam, Netherlands)     Volume:  14     ISSN:  1607-8888     ISO Abbreviation:  Stress     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-13     Completed Date:  2011-10-07     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  9617529     Medline TA:  Stress     Country:  England    
Other Details:
Languages:  eng     Pagination:  439-47     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Affect / physiology*
Exercise / physiology*,  psychology*
Female
Humans
Interleukin 1 Receptor Antagonist Protein / blood
Interleukin-1 / blood
Interleukin-10 / blood*
Male
Tumor Necrosis Factor-alpha / blood
Grant Support
ID/Acronym/Agency:
FS/09/049/27874//British Heart Foundation; RG/05/006//British Heart Foundation; RG/10/005/28296//British Heart Foundation
Chemical
Reg. No./Substance:
0/Interleukin 1 Receptor Antagonist Protein; 0/Interleukin-1; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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