Document Detail


The effects of exercise on spatial learning and anxiety-like behavior are mediated by an IGF-I-dependent mechanism related to hippocampal neurogenesis.
MedLine Citation:
PMID:  18086533     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Knowledge about the effects of physical exercise on brain is accumulating although the mechanisms through which exercise exerts these actions remain largely unknown. A possible involvement of adult hippocampal neurogenesis (AHN) in the effects of exercise is debated while the physiological and pathological significance of AHN is under intense scrutiny. Recently, both neurogenesis-dependent and independent mechanisms have been shown to mediate the effects of physical exercise on spatial learning and anxiety-like behaviors. Taking advantage that the stimulating effects of exercise on AHN depend among others, on serum insulin-like growth factor I (IGF-I), we now examined whether the behavioral effects of running exercise are related to variations in hippocampal neurogenesis, by either increasing or decreasing it according to serum IGF-I levels. Mutant mice with low levels of serum IGF-I (LID mice) had reduced AHN together with impaired spatial learning. These deficits were not improved by running. However, administration of exogenous IGF-I ameliorated the cognitive deficit and restored AHN in LID mice. We also examined the effect of exercise in LID mice in the novelty-suppressed feeding test, a measure of anxiety-like behavior in laboratory animals. Normal mice, but not LID mice, showed reduced anxiety after exercise in this test. However, after exercise, LID mice did show improvement in the forced swim test, a measure of behavioral despair. Thus, many, but not all of the beneficial effects of exercise on brain function depend on circulating levels of IGF-I and are associated to increased hippocampal neurogenesis, including improved cognition and reduced anxiety.
Authors:
J L Trejo; M V Llorens-Martín; I Torres-Alemán
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Publication Detail:
Type:  Journal Article     Date:  2007-11-05
Journal Detail:
Title:  Molecular and cellular neurosciences     Volume:  37     ISSN:  1044-7431     ISO Abbreviation:  Mol. Cell. Neurosci.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-04     Completed Date:  2008-04-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100095     Medline TA:  Mol Cell Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  402-11     Citation Subset:  IM    
Affiliation:
Cajal Institute, CSIC, Doctor Arce 37, 28002 Madrid, Spain. jltrejo@cajal.csic.es
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MeSH Terms
Descriptor/Qualifier:
Animals
Anxiety Disorders / drug therapy,  genetics*,  physiopathology
Cell Proliferation
Cognition / drug effects,  physiology
Depressive Disorder / drug therapy,  genetics,  physiopathology
Exercise Therapy
Hippocampus / metabolism*
Insulin-Like Growth Factor I / genetics,  metabolism*,  pharmacology
Learning / drug effects,  physiology
Memory / drug effects,  physiology
Memory Disorders / drug therapy,  genetics*,  physiopathology
Mice
Mice, Inbred C57BL
Mice, Mutant Strains
Neuronal Plasticity / physiology*
Neurons / metabolism
Physical Conditioning, Animal*
Stem Cells / metabolism
Swimming / physiology,  psychology
Chemical
Reg. No./Substance:
67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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