Document Detail

The effects of exercise and exercise-related changes in blood nitric oxide level on migraine headache.
MedLine Citation:
PMID:  12971707     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To observe the effects of moderate aerobic exercise on migraine headache, to assess exercise-related changes in blood nitric oxide (NO) levels, and to examine the impact of such changes on migraine attacks. DESIGN: Controlled clinical trial. SETTING: School of Physical Therapy and Rehabilitation. SUBJECTS: Forty women with general migraine attending the Neurology Department of the Faculty of Medicine Faculty of Dokuz Eylül University. INTERVENTION: Patients were assigned alternately into two groups: exercise group undertaking 1 hour aerobic exercise three times weekly, and a control group. MAIN OUTCOME MEASURES: Patients were assessed before and after treatment using three clinical scales--visual analogue scale for headache, Pain Disability Index and Quality of Life Scale--and chemiluminescence analysis for plasma nitric oxide. RESULTS: After the eight-week therapy period, patient complaints concerning the intensity, frequency and duration of pain had decreased significantly in both groups; however, visual analogue scale scoring showed better pain relief in the exercised group than in the controls (from 8.8 +/- 1.7 to 4.0 +/- 1.4 and from 8.5 +/- 0.8 to 7.0 +/- 0.9 respectively). Quality of life measures also revealed better migraine relief in the exercised women than in those who received medical treatment only. Blood NO rose significantly from pre- to post-therapy in the exercised group, but the change was not significant in the control group. CONCLUSION: The study showed that regular long-term aerobic exercise reduced migraine pain severity, frequency and duration possibly due to increased nitric oxide production.
S Osün Narin; L Pinar; D Erbas; V Oztürk; F Idiman
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Clinical rehabilitation     Volume:  17     ISSN:  0269-2155     ISO Abbreviation:  Clin Rehabil     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-15     Completed Date:  2003-12-23     Revised Date:  2006-09-18    
Medline Journal Info:
Nlm Unique ID:  8802181     Medline TA:  Clin Rehabil     Country:  England    
Other Details:
Languages:  eng     Pagination:  624-30     Citation Subset:  IM    
School of Physical Therapy and Rehabilitation, Dokuz Eylül University, Izmir, Turkey.
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MeSH Terms
Exercise Therapy / methods*
Migraine Disorders / blood,  rehabilitation*
Nitric Oxide / blood*
Pain / classification
Pain Measurement
Quality of Life*
Reg. No./Substance:
10102-43-9/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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