Document Detail


The effects of exercise on the pharmacokinetics of drugs.
MedLine Citation:
PMID:  11293389     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
According to the limited information available, exercise has no substantial effect on the absorption of orally given drugs. However, it appears to enhance absorption from intramuscular, subcutaneous, transdermal and inhalation sites. The effects of exercise on drug distribution are complex. Exercise increases muscular blood flow resulting, for example, in the increased binding of digoxin in working skeletal muscle. On the other hand, exercise may sequester some drugs such as propranolol in muscle and reduce the availability of the drug for elimination. In addition, exercise decreases the clearance of highly extracted drugs and increases their plasma concentration. It may also increase the clearance of drugs by increasing biliary excretion. Since exercise reduces renal blood flow, the plasma concentrations of those drugs which are primarily eliminated by the kidneys may increase. In conclusion, if maintaining the plasma concentration of a drug at a certain level is important, consideration should be given to alternative drugs if the patient is on intermittent or irregular exercise.
Authors:
T Khazaeinia; A A Ramsey; Y K Tam
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques     Volume:  3     ISSN:  1482-1826     ISO Abbreviation:  J Pharm Pharm Sci     Publication Date:    2000 Sep-Dec
Date Detail:
Created Date:  2001-04-06     Completed Date:  2001-05-31     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9807281     Medline TA:  J Pharm Pharm Sci     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  292-302     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Absorption
Bile Ducts, Extrahepatic / metabolism
Exercise / physiology*
Gastric Emptying / physiology
Humans
Kidney / metabolism*
Liver / metabolism*
Metabolic Clearance Rate
Pharmacokinetics*
Tissue Distribution

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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