Document Detail

The effects of exercise on lipogenic enzyme activity and glyceride synthesis by liver homogenates of diabetic rats.
MedLine Citation:
PMID:  3657516     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to determine if exercise ameliorates the elevated levels of triglycerides in diabetic rats and also to determine if the capacity of liver to synthesize glycerides correlates with changes in plasma triglyceride levels. Forty female rats were divided into four groups: sedentary control, sedentary diabetic, exercised control, and exercised diabetic. Diabetes was induced by intravenous injection of alloxan (40 mg/kg), and control rats were sham-dosed with physiologic saline. All rats remained sedentary in their cages for the first week after the injections. The exercised groups were exercised for seven consecutive days for 2 h/d at 20 m/min (0 grade). All rats were killed 24 hours after the last exercise bout. Blood glucose levels were significantly higher in the diabetic group than the nondiabetic counterparts, but exercise did not affect glucose levels in either the diabetic or nondiabetic groups. Exercise, however, significantly lowered plasma triglyceride and free fatty acid levels in both diabetic and nondiabetic rats. The activities of the five enzymes involved in fatty acid synthesis were all depressed in the diabetic rats compared to controls, and exercise had no effect on the activities of the enzymes. The capacity of liver to synthesize total lipids, diglycerides, or triglycerides was not different in the diabetic rats from that of nondiabetic rats, and exercise did not change that. Only phospholipid synthesis from glycerol-3-phosphate was affected by diabetes. It is concluded that exercise ameliorates the elevations in plasma triglyceride levels that result from diabetes.(ABSTRACT TRUNCATED AT 250 WORDS)
H A Barakat; J W Carpenter; Y A Lennon; W R Hanna; K F O'Brien; G L Dohm
Related Documents :
3403486 - Sympathetic neural influences on muscle blood flow in rats during submaximal exercise.
11487706 - A decrease in soleus muscle force generation in rats after downhill running.
21038936 - Interpreting the effects of exercise on fear conditioning: the influence of time of day.
18317386 - Exercise reduces inflammation and cell proliferation in rat colon carcinogenesis.
11739086 - Control of glycolysis in contracting skeletal muscle. ii. turning it off.
18619126 - Combat stress or hemorrhage? evidence for a decision-assist algorithm for remote triage.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  36     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1987-11-05     Completed Date:  1987-11-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  983-7     Citation Subset:  IM    
Department of Biochemistry, School of Medicine, East Carolina University, Greenville, NC 27858.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Diabetes Mellitus, Experimental / blood,  metabolism*
Fatty Acids / biosynthesis
Fatty Acids, Nonesterified / blood
Glycerides / biosynthesis*
Liver / enzymology,  metabolism*
Physical Exertion*
Triglycerides / blood*
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Nonesterified; 0/Glycerides; 0/Triglycerides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Whole body lipid and energy metabolism in the cancer patient.
Next Document:  Glycoconjugates as noninvasive probes of intrahepatic metabolism: I. Kinetics of label incorporation...