Document Detail


The effects of exercise on lipogenic enzyme activity and glyceride synthesis by liver homogenates of diabetic rats.
MedLine Citation:
PMID:  3657516     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to determine if exercise ameliorates the elevated levels of triglycerides in diabetic rats and also to determine if the capacity of liver to synthesize glycerides correlates with changes in plasma triglyceride levels. Forty female rats were divided into four groups: sedentary control, sedentary diabetic, exercised control, and exercised diabetic. Diabetes was induced by intravenous injection of alloxan (40 mg/kg), and control rats were sham-dosed with physiologic saline. All rats remained sedentary in their cages for the first week after the injections. The exercised groups were exercised for seven consecutive days for 2 h/d at 20 m/min (0 grade). All rats were killed 24 hours after the last exercise bout. Blood glucose levels were significantly higher in the diabetic group than the nondiabetic counterparts, but exercise did not affect glucose levels in either the diabetic or nondiabetic groups. Exercise, however, significantly lowered plasma triglyceride and free fatty acid levels in both diabetic and nondiabetic rats. The activities of the five enzymes involved in fatty acid synthesis were all depressed in the diabetic rats compared to controls, and exercise had no effect on the activities of the enzymes. The capacity of liver to synthesize total lipids, diglycerides, or triglycerides was not different in the diabetic rats from that of nondiabetic rats, and exercise did not change that. Only phospholipid synthesis from glycerol-3-phosphate was affected by diabetes. It is concluded that exercise ameliorates the elevations in plasma triglyceride levels that result from diabetes.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
H A Barakat; J W Carpenter; Y A Lennon; W R Hanna; K F O'Brien; G L Dohm
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  36     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1987-11-05     Completed Date:  1987-11-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  983-7     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, School of Medicine, East Carolina University, Greenville, NC 27858.
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MeSH Terms
Descriptor/Qualifier:
Animals
Diabetes Mellitus, Experimental / blood,  metabolism*
Fatty Acids / biosynthesis
Fatty Acids, Nonesterified / blood
Female
Glycerides / biosynthesis*
Liver / enzymology,  metabolism*
Physical Exertion*
Rats
Triglycerides / blood*
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Nonesterified; 0/Glycerides; 0/Triglycerides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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