Document Detail

The effects of exercise following exposure to bis(trifluoromethyl) disulfide.
MedLine Citation:
PMID:  1811957     Owner:  NLM     Status:  MEDLINE    
Bis(trifluoromethyl) disulfide (TFD) was originally designed for use as an agricultural fumigant. Inhalation of toxic doses of TFD results in varying degrees of pulmonary edema. The purpose of this study was to determine if exhaustive exercise would potentiate the toxic effects of TFD. One group of treadmill-acclimated rats was exercised to exhaustion following a 10-minute whole-body exposure to TFD. A second group was similarly exposed but not exercised. Two other groups of rats were sham exposed; one was exercised while one remained sedentary following the sham exposure. Twenty-four hours after exposure, the animals were sacrificed; the lungs were removed and weighed, and a portion was collected for histopathologic examination. The remaining lung tissue was allowed to dry to constant weight. There was no difference in endurance times between exposed and sham-exposed rats. There was a significant increase in the amount of pulmonary edema and associated pulmonary pathology in rats exercised following exposure to TFD. Eleven of twelve animals exercised following exposure to TFD and three of twelve animals which remained sedentary following exposure died by 24 hours. The degree of pulmonary pathology in all rats exposed to TFD was profound.
D H Moore; H G Wall
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drug and chemical toxicology     Volume:  14     ISSN:  0148-0545     ISO Abbreviation:  Drug Chem Toxicol     Publication Date:  1991  
Date Detail:
Created Date:  1992-06-10     Completed Date:  1992-06-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7801723     Medline TA:  Drug Chem Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  343-52     Citation Subset:  IM    
United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland 21010-5425.
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MeSH Terms
Administration, Inhalation
Analysis of Variance
Disulfides / administration & dosage,  toxicity*
Dose-Response Relationship, Drug
Fluorocarbons / administration & dosage,  toxicity*
Lung / drug effects
Organ Size / drug effects
Physical Exertion*
Pulmonary Edema / chemically induced*
Rats, Inbred Strains
Reg. No./Substance:
0/Disulfides; 0/Fluorocarbons; 372-64-5/bis(trifluoromethyl)disulfide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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