Document Detail

The effects of exercise capacity and sedentary lifestyle on haemostasis among middle-aged women with coronary heart disease.
MedLine Citation:
PMID:  18989536     Owner:  NLM     Status:  MEDLINE    
Previous studies have established a link/relationship between haemostatic factors and increased risk of cardiovascular disease. In addition, physical conditioning is associated with lower coronary heart disease risk. The purpose of this study was to assess the association between physical exercise and haemostatic factors among middle-aged women surviving an acute coronary event. The Stockholm Female Coronary Risk Study included 292 women aged < 65 years, resident in the greater Stockholm area, who were hospitalized for an acute coronary syndrome. Extensive clinical screening including exercise testing, and blood tests were performed 3-6 months after the coronary event. Self-reported physical activity was assessed by a WHO questionnaire. Patients on warfarin treatment were excluded from our analyses. Haemostatic factors were generally higher among physically inactive patients when compared to physically active women in our univariate models. Exercise capacity had a statistically significant relationship with factor VII antigen (p = 0.039) and vWFag (p = 0.038) even in our multiadjusted analyses. Physical inactivity and poor physical fitness are associated with a potentially prothrombotic blood profile in middle aged women with coronary heart disease.
Edit Nagy; Imre Janszky; Margita Eriksson-Berg; Faris Al-Khalili; Karin Schenck-Gustafsson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  100     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-07     Completed Date:  2008-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  899-904     Citation Subset:  IM    
Divison of Medicine, Cardiology Unit, Karolinska University Hospital and Karolinska Institutet, SE-171 76 Stockholm, Sweden.
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MeSH Terms
Acute Coronary Syndrome / blood,  etiology*,  physiopathology
Coronary Disease / blood*,  complications,  physiopathology
Exercise Tolerance*
Factor VII / analysis
Life Style*
Middle Aged
von Willebrand Factor / analysis
Reg. No./Substance:
0/von Willebrand Factor; 9001-25-6/Factor VII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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