Document Detail


The effects of excipients for topical preparations on the human skin permeability of terpinen-4-ol contained in Tea tree oil: infrared spectroscopic investigations.
MedLine Citation:
PMID:  19842911     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This work aimed to evaluate the effect induced by excipients conventionally used for topical dosage forms, namely isopropyl myristate (IPM) or oleic acid (OA) or polyethylene glycol 400 (PEG400) or Transcutol (TR), on the human skin permeability of terpinen-4-ol (T4OL) contained in the pure Tea tree oil. The effect of such excipients was determined by evaluating the absorption of T4OL using human epidermis and the perturbation of the organization of stratum corneum by ATR-FTIR. Among the tested excipients OA enhanced the absorption of T4OL by perturbing the stratum corneum lipid barrier. Other excipients caused a weak enhancement effect and their use should be carefully monitored.
Authors:
Antonella Casiraghi; Paola Minghetti; Francesco Cilurzo; Francesca Selmin; Veniero Gambaro; Luisa Montanari
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmaceutical development and technology     Volume:  15     ISSN:  1097-9867     ISO Abbreviation:  Pharm Dev Technol     Publication Date:    2010 Sep-Oct
Date Detail:
Created Date:  2010-08-25     Completed Date:  2010-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610932     Medline TA:  Pharm Dev Technol     Country:  England    
Other Details:
Languages:  eng     Pagination:  545-52     Citation Subset:  IM    
Affiliation:
Istituto di Chimica Farmaceutica e Tossicologica, Università degli Studi di Milano, Italy. antonella.casiraghi@unimi.it
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Epidermis / drug effects,  metabolism
Excipients / administration & dosage,  pharmacology*
Female
Humans
Permeability
Skin / drug effects*,  metabolism
Skin Absorption / drug effects*
Spectroscopy, Fourier Transform Infrared
Tea Tree Oil / chemistry,  metabolism*
Terpenes / chemistry,  metabolism*
Chemical
Reg. No./Substance:
0/Excipients; 0/Terpenes; 562-74-3/terpinenol-4; 68647-73-4/Tea Tree Oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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