Document Detail

The effects of ergonovine maleate on coronary arterial size.
MedLine Citation:
PMID:  758127     Owner:  NLM     Status:  MEDLINE    
Changes in coronary arterial size due to ergonovine maleate are described and quantitated in 90 patients--18 with typical angina pectoris, 56 with atypical chest pain, nine with variant angina pectoris, and seven heart transplant (allograft) recipients. We observed two angiographic changes in the diameter of coronary arteries: 1) spasm, which was characterized by occlusion or marked (greater than 85%) focal or diffuse vessel narrowing, or 2) relatively mild and diffuse vessel narrowing, which was interpreted as the normal pharmacologic response to the drug. Serial bolus injections of 0.05 mg, 0.10 mg and 0.25 mg of ergonovine maleate produced diffuse narrowing of the diameter of coronary arteries of 10 +/- 1.5%, 16 +/- 1.4% and 20 +/- 1.3% (mean +/- SEM), respectively, in the 72 patients with anginal syndromes who did not develop coronary spasm. The degree of coronary arterial narrowing was the same in heart transplant recipients and in patients with normally innervated hearts who did not develop coronary spasm. We believe the normal pharmacologic response to ergonovine maleate was due to a direct vasoconstrictor action of the drug; this action was independent of neural control extrinsic to the heart.
P R Cipriano; D F Guthaner; A E Orlick; D R Ricci; L Wexler; J F Silverman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation     Volume:  59     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1979 Jan 
Date Detail:
Created Date:  1979-01-26     Completed Date:  1979-01-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  82-9     Citation Subset:  AIM; IM    
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MeSH Terms
Analysis of Variance
Coronary Angiography
Coronary Disease / radiography*
Coronary Vessels / drug effects*
Dose-Response Relationship, Drug
Ergonovine / administration & dosage,  diagnostic use*
Middle Aged
Models, Biological
Spasm / chemically induced*
Reg. No./Substance:

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