Document Detail

The effects of endocannabinoid signaling on network activity in developing and motor circuits.
MedLine Citation:
PMID:  23531011     Owner:  NLM     Status:  In-Data-Review    
Endocannabinoid signaling typically mediates a form of synaptic plasticity in which a postsynaptic cell acts retrogradely to reduce vesicle release from presynaptic terminals impinging on that cell. In the embryonic spinal cord, endocannabinoids inhibit spontaneously released glutamatergic vesicles in both a brief and ongoing tonic manner. Together these endocannabinoid-mediated forms of synaptic regulation appear to play an important role in regulating the frequency of a form of spontaneous network activity (SNA) that is expressed in the embryonic spinal cord. Because of the importance of SNA to the maturation of the developing network, fetal exposure to drugs that influence endocannabinoid signaling may have profound effects on spinal maturation. In this review, endocannabinoid signaling in the embryonic spinal cord is described and compared to signaling in the mature lamprey spinal cord as well as in the developing hippocampal network, which expresses a form of SNA.
Peter Wenner
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1279     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  135-42     Citation Subset:  IM    
Copyright Information:
© 2013 New York Academy of Sciences.
Department of Physiology, Emory University School of Medicine, Atlanta, Georgia.
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