Document Detail


The effects of dopaminergic agents on the locomotor activity of rats after high doses of methylamphetamine.
MedLine Citation:
PMID:  7422696     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Treatment of rats with 100 mg/kg/day of methylamphetamine for four days produced long lasting (16 week) depletions of central nervous system levels of dopamine but not of norepinephrine. This methylamphetamine treatment also attenuated the ability of methylamphetamine and apomorphine to produce increases in locomotor activity without shifting the dose-response curve to the right or left. These rats underwent significant decreases in activity after lower doses of haloperidol while the response to L-Dopa was virtually unchanged.
Authors:
J B Lucot; G C Wagner; C R Schuster; L S Seiden
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  13     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1980 Sep 
Date Detail:
Created Date:  1980-12-18     Completed Date:  1980-12-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  409-13     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Chemistry / drug effects
Dopamine / physiology*
Drug Interactions
Haloperidol / pharmacology
Levodopa / pharmacology
Male
Methamphetamine / pharmacology*
Motor Activity / drug effects*
Rats
Grant Support
ID/Acronym/Agency:
DA 11250/DA/NIDA NIH HHS; DA-00085/DA/NIDA NIH HHS; MH 14274/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Levodopa; 52-86-8/Haloperidol; 537-46-2/Methamphetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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