| The effects of dopamine, ephinephrine, and esmolol on the hemodynamic energy in terms of the energy equivalent pressure. | |
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MedLine Citation:
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PMID: 18043167 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The generation of pulsatile flow depends on the hemodynamic energy gradient rather than the pressure gradient. We hypothesized that either positive or negative inotropic agents can affect the hemodynamic energy, which can be measured using the energy equivalent pressure (EEP) and surplus hemodynamic energy (SHE). This study examined the change in hemodynamic energy induced by dopamine, epinephrine, and esmolol infusion in terms of the EEP and SHE. Dopamine (5, 10 microg/kg/min), epinephrine (0.02, 0.1 microg/kg/min) and esmolol (after bolus 1 mg/kg, 0.1, 0.3 mg/kg/min) were infused into six anesthetized dogs. The hemodynamic parameters were collected in the descending thoracic aorta. The mean arterial pressure, blood flow, EEP, and SHE increased significantly with the dopamine infusion. The mean arterial pressure and EEP decreased significantly after the esmolol infusion, while it increased after the epinephrine infusion (p < 0.05 respectively). There was a correlation between the EEP and flow on the descending aorta during the dopamine, esmolol and epinephrine infusions (p < 0.05 respectively). In conclusion, the change in hemodynamic energy induced by dopamine, esmolol, and epinephrine may be expressed in terms of the EEP and SHE. In addition, there was a strong correlation between the EEP and flow. |
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Authors:
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Choon Hak Lim; Ho Sung Son; Yung Hu Fang; Jung Joo Lee; Hye Won Lee; Kyung Sun |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: ASAIO journal (American Society for Artificial Internal Organs : 1992) Volume: 53 ISSN: 1538-943X ISO Abbreviation: ASAIO J. Publication Date: 2007 Nov-Dec |
Date Detail:
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Created Date: 2007-11-28 Completed Date: 2008-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204109 Medline TA: ASAIO J Country: United States |
Other Details:
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Languages: eng Pagination: 791-4 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology and Pain Medicine, Korea University, Seoul, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta, Thoracic / drug effects Blood Flow Velocity / drug effects Blood Pressure / drug effects Dogs Dopamine / administration & dosage, pharmacology* Dose-Response Relationship, Drug Energy Metabolism / drug effects* Epinephrine / administration & dosage, pharmacology* Hemodynamics / drug effects* Infusions, Intravenous Propanolamines / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Propanolamines; 51-43-4/Epinephrine; 84057-94-3/esmolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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