Document Detail


The effects of dopamine on central hemodynamics and myocardial metabolism in experimental propoxyphene-induced shock.
MedLine Citation:
PMID:  4061011     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hemodynamic and cardiometabolic effects of dopamine were evaluated in propoxyphene-induced circulatory shock in eight pentobarbital anesthetized pigs. Circulatory shock was induced by an infusion of propoxyphene chloride 15 mg . min-1 i.v. At shock, i.e. CI less than or equal to 2.0 l . min-1 . m-2 and/or MAP less than or equal to 60 mmHg, dopamine was infused at 10, 20, 40, 80 and 160 micrograms . kg-1 . min-1 with an interval between increments of 8 min. After 30 min at 160 micrograms . kg-1 . min-1, the infusion rate was reversibly decreased. The propoxyphene infusion of 15 mg . min-1 was continued throughout the study. Dopamine improved the circulation in seven animals; one animal died in refractory shock during dopamine infusion. Dopamine infusion at shock level resulted in an increase of the following variables (% of baseline value): MAP (69%), HR (109%), CI (138%) and SVI (129%). Normalisation was seen in MRAP (120%) and in MPAOP (100%). A profound decrease in systemic vascular resistance was unchanged. Increases were seen in left and right ventricular stroke work index, to 88% and 176% of baseline, respectively. Left ventricular dP/dt increased (170%). In the coronary circulation myocardial blood flow increased (133%) as did myocardial oxygen consumption (65%) concomitant with a decrease in myocardial oxygen uptake (41%), but coronary vascular resistance progressively decreased (38%). The myocardial propoxyphene extraction changed from +54% to -86% during peak dopamine infusion. In conclusion, dopamine reversed cardiac failure in propoxyphene overdose by a marked positive inotropic stimulation restoring contractility. A marked positive chronotropic stimulation maintained a sufficient cardiac index and a normal blood pressure in spite of a profound vasodilatation which was unresponsive to dopamine.
Authors:
J Strøm; S Häggmark; H Nyhman; S Reiz; P S Madsen; H Angelo; M Bredgaard Sørensen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  29     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1985-12-19     Completed Date:  1985-12-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  643-50     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Coronary Circulation / drug effects
Dextropropoxyphene / blood,  toxicity*
Dopamine / pharmacology*
Electrocardiography
Hemodynamics / drug effects*
Myocardium / metabolism*
Oxygen Consumption / drug effects
Shock / chemically induced,  physiopathology*
Chemical
Reg. No./Substance:
469-62-5/Dextropropoxyphene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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