Document Detail


The effects of the dopamine D2 agonist sumanirole on prepulse inhibition in rats.
MedLine Citation:
PMID:  20346635     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dopamine agonists reduce prepulse inhibition (PPI) of startle in rats. While it is used to predict antipsychotic efficacy, the specific receptor subtypes mediating this effect of dopamine agonists remain unclear. We characterized the effects of sumanirole, a highly selective D2 agonist, on PPI in rats. Sumanirole decreased PPI at 60-120 ms prepulse intervals, and increased PPI at 10-20 ms intervals. PPI deficits were antagonized by low doses of the preferential D2 antagonist L741626, supporting a D2 mechanism of action. Sumanirole is a valuable tool for parsing the role of dopamine receptor subtypes in the regulation of PPI.
Authors:
Martin Weber; Wei-Li Chang; Michelle R Breier; Alex Yang; Mark J Millan; Neal R Swerdlow
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-03-25
Journal Detail:
Title:  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology     Volume:  20     ISSN:  1873-7862     ISO Abbreviation:  Eur Neuropsychopharmacol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-04     Completed Date:  2010-07-29     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  9111390     Medline TA:  Eur Neuropsychopharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  421-5     Citation Subset:  IM    
Copyright Information:
2010 Elsevier B.V. and ECNP. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Animals
Benzimidazoles / pharmacology*
Discrimination (Psychology)
Dopamine Agonists / pharmacology*
Dose-Response Relationship, Drug
Hypothermia / chemically induced
Male
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D2 / agonists*
Receptors, Dopamine D3 / drug effects
Startle Reaction / drug effects*
Grant Support
ID/Acronym/Agency:
K02 MH001436/MH/NIMH NIH HHS; K02 MH001436-10/MH/NIMH NIH HHS; MH01436/MH/NIMH NIH HHS; MH68366/MH/NIMH NIH HHS; R01 MH068366/MH/NIMH NIH HHS; R01 MH068366-06/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Benzimidazoles; 0/Dopamine Agonists; 0/Receptors, Dopamine D2; 0/Receptors, Dopamine D3; 2OI87T3R1B/U 95666E
Comments/Corrections

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