Document Detail

The effects of dobutamine therapy in critically ill patients measured by transoesophageal echocardiography and intracardiac monitoring.
MedLine Citation:
PMID:  8209989     Owner:  NLM     Status:  MEDLINE    
Fourteen patients with severe hypotension and adult respiratory distress syndrome after trauma (n = 7), general surgery (n = 6) or burns (n = 1) were studied. After volume loading with 6 hydroxyethyl starch over 30 min (time I), dobutamine was infused intravenously at 5 (time II) and 10 (time III). A 5 MHz transoesophageal echocardiographic probe was used to image a standard transgastric short axis view of the left ventricle. Haemodynamic data were obtained from thermodilution studies using pulmonary flotation catheterisation. Echocardiographic measurements (off-line from videotape) and qualitative visual assessment of left ventricular function (visual assessment, on-line) were performed. All measurements were made after fluid replacement, and during infusion of the two dobutamine doses. An improvement in mean systemic arterial blood pressure and mean stroke volume occurred from time I to the end of dobutamine infusion (p < 0.05). All patients, after volume infusion, were normovolaemic according to transoesophageal echocardiography and there was a good correlation between end-diastolic area and stroke volume (r = 0.73). During dobutamine infusion, echocardiographic measurements showed no significant dose-related increase in mean (SD) percentage left ventricular short axis area change from baseline after hydroxyethyl starch (time I: 60 (2); time II: 63 (2); time III: 64 (2)). However, a significant increase in short axis area change was seen in nine of the 14 patients (67%). Analysis of the end-diastolic area/short axis area change relationship revealed a heterogeneous response to dobutamine.(ABSTRACT TRUNCATED AT 250 WORDS)
H Steltzer; P Simon; A N Owen; M Thalmann; A F Hammerle
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anaesthesia     Volume:  49     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-07-11     Completed Date:  1994-07-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  432-7     Citation Subset:  AIM; IM    
Department of Anaesthesia, University of Vienna, Austria.
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MeSH Terms
Dobutamine / therapeutic use*
Drug Administration Schedule
Echocardiography, Transesophageal*
Heart Catheterization*
Hemodynamics / drug effects*
Middle Aged
Postoperative Complications / drug therapy,  ultrasonography
Respiratory Distress Syndrome, Adult / drug therapy*,  ultrasonography
Reg. No./Substance:

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