| The effects of diuretics and adrenergic-blocking agents on plasma lipids. | |
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MedLine Citation:
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PMID: 2876554 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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ANTIHYPERTENSIVE MEDICATIONS CAUSE THE FOLLOWING CHANGES IN PLASMA LIPIDS AND LIPOPROTEINS: Thiazide and loop diuretics increase triglyceride, total cholesterol and low-density-lipoprotein (LDL) cholesterol levels with no change in high-density-lipoprotein (HDL) cholesterol. beta-Adrenergic antagonists increase triglyceride and decrease HDL cholesterol levels. A rise in very-low-density-lipoprotein (VLDL) cholesterol balances the decrease in HDL cholesterol, so that there is no significant change in total cholesterol. alpha-Adrenergic antagonists decrease triglyceride, increase HDL cholesterol and may decrease VLDL and LDL cholesterol. Labetalol, with both alpha- and beta-adrenergic antagonistic activity, does not affect plasma lipids in a small number of studies. The calcium channel blockers nifedipine and verapamil also have no consistent effect on lipoprotein levels in a small number of studies. |
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Authors:
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J J Rohlfing; J D Brunzell |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: The Western journal of medicine Volume: 145 ISSN: 0093-0415 ISO Abbreviation: West. J. Med. Publication Date: 1986 Aug |
Date Detail:
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Created Date: 1986-11-03 Completed Date: 1986-11-03 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0410504 Medline TA: West J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 210-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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therapeutic use* Diuretics / therapeutic use* Humans Hypertension / blood, drug therapy* Lipids / blood* |
| Grant Support | |
ID/Acronym/Agency:
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AM 02456/AM/NIADDK NIH HHS; HL 30086/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Diuretics; 0/Lipids |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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