Document Detail

The effects of distamycin A on gorilla-, chimpanzee- and orangutan lymphocyte cultures.
MedLine Citation:
PMID:  7297124     Owner:  NLM     Status:  MEDLINE    
Lymphocyte cultures from the gorilla, chimpanzee, and orangutan were treated with the oligopeptide antibiotic distamycin A. This AT-specific DNA-ligand induces a distinct undercondensation in the quinacrine-bright heterochromatin of the gorilla and chimpanzee. This is also the case in human lymphocyte cultures. Distamycin A further causes an undercondensation in the nonheterochromatic bands 17q21 of the gorilla and 16q22 of man. No visible distamycin A-sensitive chromosome regions are determined in the orangutan. The in vitro treatment with distamycin A preserves the somatic pairings between the quinacrine-bright heterochromatic regions existing in the interphase nucleus until the succeeding metaphase stage. The phylogenetic origin of the quinacrine-bright and distamycin A-sensitive heterochromatin in the ancestor of man, the gorilla, and the chimpanzee is discussed.
M Schmid; A Poppen; W Engel
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cytogenetics and cell genetics     Volume:  30     ISSN:  0301-0171     ISO Abbreviation:  Cytogenet. Cell Genet.     Publication Date:  1981  
Date Detail:
Created Date:  1982-01-09     Completed Date:  1982-01-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367735     Medline TA:  Cytogenet Cell Genet     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  211-21     Citation Subset:  IM    
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MeSH Terms
Cells, Cultured
Chromosome Banding
Chromosomes / ultrastructure*
Distamycins / pharmacology*
Gorilla gorilla / genetics*
Hominidae / genetics*
Lymphocytes / ultrastructure
Pan troglodytes / genetics*
Pongo pygmaeus / genetics*
Pyrroles / pharmacology*
Species Specificity
Reg. No./Substance:
0/Distamycins; 0/Pyrroles

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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