Document Detail

The effects of dipyridamole on coronary post-occlusion hyperaemia and on myocardial vasodilatation induced by systemic hypoxia.
MedLine Citation:
PMID:  4655264     Owner:  NLM     Status:  MEDLINE    
1. The arterial pO(2) of anaesthetized cats was reduced to 33 mmHg by supplying a mixture of oxygen and nitrogen as the respiratory gas. This produced vasodilatation in the myocardial bed which was not increased after the injection of dipyridamole (1 mg/kg).2. Reactive hyperaemia was observed following occlusion of the left anterior descending coronary artery for 10-120 seconds. The duration of the period of reactive hyperaemia was increased after the injection of dipyridamole. This effect of dipyridamole was most pronounced when the longest periods of occlusion were used.3. These results support the hypothesis that myocardial reactive hyperaemia is at least partly caused by adenosine released from hypoxic myocardial cells. The vasodilatation occurring during systemic hypoxia, on the other hand, is probably mediated via a different mechanism.
J R Parratt; R M Wadsworth
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  46     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1972 Dec 
Date Detail:
Created Date:  1973-05-02     Completed Date:  1973-05-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  594-601     Citation Subset:  IM    
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MeSH Terms
Anoxia / physiopathology*
Benzoates / pharmacology
Blood Pressure
Coronary Vessels / drug effects*
Dipyridamole / pharmacology*
Heart / drug effects
Heart Failure / physiopathology*
Oxygen / blood
Vascular Resistance
Reg. No./Substance:
0/Benzoates; 58-32-2/Dipyridamole; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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