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The effects of diphenyl diselenide on oxidative stress biomarkers in Cyprinus carpio exposed to herbicide quinclorac (Facet(®)).
MedLine Citation:
PMID:  22608528     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The occurrence of pollutants in the aquatic environment can produce severe toxic effects on non-target organisms, including fish. These sources of contamination are numerous and include herbicides, which represent a large group of toxic chemicals. Quinclorac, an herbicide widely applied in agriculture, induces oxidative stress due to free radical generation and changes in the antioxidant defense system. The aim of this study was to assess if dietary diphenyl diselenide (PhSe)(2) has a protective effect in tissues of fish species Cyprinus carpio exposed to the quinclorac herbicide. The fish were fed with either a standard or a diet containing 3.0mg/Kg of diphenyl diselenide for 60d. After were exposed to 1mg/L of Facet(®) (quinclorac commercial formulation) for 192h. At the end of the experimental period, parameters as thiobarbituric acid-reactive substance levels (TBARS), protein carbonyl, catalase (CAT), superoxide dismutase (SOD), glutathione S-transferase (GST), nonprotein thiols (NPSH) and ascorbic acid in the liver, gills, brain and muscle were evaluated in Cyprinus carpio. In fish exposed to quinclorac and feeding with standard diet TBARS levels increased in liver and gills. However, SOD activity decreases in liver whereas no alterations were observed in catalase activity in this tissue. Quinclorac also decrease GST activity in liver and brain, NPSH in brain and muscle and ascorbic acid in muscle. Concerning protein carbonyl exposed to herbicide the fish did not show any alterations. The diphenyl diselenide supplemented diet reversed these effects, preventing increases in TBARS levels in liver and gills. GST activity was recovered to control values in liver. NPSH levels in brain and muscle increased remain near to control values. These results indicated that dietary diphenyl diselenide protects tissues against quinclorac induced oxidative stress ameliorating the antioxidant properties.
Authors:
Charlene Cavalheiro de Menezes; Jossiele Leitemperger; Adriana Santi; Thais Lópes; Cátia Aline Veiverberg; Sandra Peixoto; Martha Bohrer Adaime; Renato Zanella; Nilda Berenice Vargas Barbosa; Vania Lucia Loro
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-18
Journal Detail:
Title:  Ecotoxicology and environmental safety     Volume:  -     ISSN:  1090-2414     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7805381     Medline TA:  Ecotoxicol Environ Saf     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Programa de Pós-Graduação em Bioquímica Toxicológica, Brazil.
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