Document Detail

The effects of diminazene aceturate on systemic blood pressure in clinically healthy adult dogs.
MedLine Citation:
PMID:  15029949     Owner:  NLM     Status:  MEDLINE    
Diminazene aceturate is a commonly used antibabesial agent. It has been postulated that diminazine may induce a decrease in blood pressure and exacerbate the hypotension presented in dogs with babesiosis. This study was undertaken to assess the effect of diminazine aceturate on the blood pressure of healthy dogs. Six healthy German shepherd dogs between 18 and 24 months of age with a mean weight of 30.4 +/- 2.75 kg were used. Blood pressure was directly measured at the following time intervals: -5, 0, 5, 10, 15, 20, 25, 30, 35, 40, 50, 60, 90 and 120 minutes after treatment with diminazine aceturate (4.2 mg/kg) intramuscularly. No statistical difference (P > 0.05) was found in blood pressure between any of the time intervals. An increase in heart rate was seen 5 minutes after the administration of diminazine aceturate but no change in blood pressure was evident. This study concluded that diminazene aceturate in its current formulation with antipyrine does not alter blood pressure in healthy adult dogs.
K E Joubert; F Kettner; R G Lobetti; D M Miller
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the South African Veterinary Association     Volume:  74     ISSN:  1019-9128     ISO Abbreviation:  J S Afr Vet Assoc     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2004-03-19     Completed Date:  2004-04-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503122     Medline TA:  J S Afr Vet Assoc     Country:  South Africa    
Other Details:
Languages:  eng     Pagination:  69-71     Citation Subset:  IM    
Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort 0110, South Africa.
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MeSH Terms
Antiprotozoal Agents / adverse effects*,  therapeutic use
Babesiosis / drug therapy,  veterinary
Blood Pressure / drug effects*
Diminazene / adverse effects*,  analogs & derivatives*,  therapeutic use
Dog Diseases / drug therapy
Dogs / physiology*
Heart Rate / drug effects
Injections, Intramuscular / veterinary
Time Factors
Reg. No./Substance:
0/Antiprotozoal Agents; 536-71-0/Diminazene; 908-54-3/diminazene aceturate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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