| The effects of dietary phospholipids enriched with phosphatidylethanolamine on bile and red cell membrane lipids in humans. | |
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MedLine Citation:
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PMID: 8900459 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of phospholipids in biliary cholesterol solubilization and crystallization has only recently begun to be appreciated. Phospholipid vesicles are believed to be the metastable carrier from which cholesterol nucleates. Cholesterol crystallization is influenced by the phospholipid species in bile. Feeding rats and hamsters with diets enriched in phospholipids or their precursors, especially ethanolamine, resulted in reduced cholesterol saturation of bile. Although whole phospholipids are normal dietary constituents, the effects and safety of phospholipid components have not been tested in humans. In the present study, we have evaluated the effects of a dietary phospholipid mixture, enriched with phosphatidylethanolamine, on human bile and red blood cell membrane lipid composition. Five ambulatory volunteers having a chronic indwelling T-tube, with an intact enterohepatic circulation, were investigated. Thirty-six grams of phospholipids (54% phosphatidylethanolamine, 54% linoleyl acyl chains) were added to their daily diet for fourteen days. Biliary nucleation time, cholesterol carriers, as well as plasma, red blood cell membrane, and bile lipid compositions, were monitored. Following phospholipid supplementation, the proportion of linoleyl chains (18:2) in biliary phospholipids increased significantly from 31.1 +/- 1.2 to 37.7 +/- 5.3%, while that of oleyl chains (18:1) decreased from 11.4 +/- 1.6 to 9.6 +/- 1.1%. These changes were accompanied by an increase of linoleate and its metabolite, arachidonate, in red cell membranes. Phospholipid feeding did not cause any side effects, and no significant changes in biliary nucleation time, cholesterol, phospholipid, or bile salt concentrations, or in the distribution of cholesterol within micelles or vesicles. We conclude that phospholipid feeding is safe, and can be effective as a vehicle for lecithin fatty acyl chain modulation of bile and lipid membranes. These findings may provide a basis for a controlled modulation of biliary phospholipids to increase cholesterol solubility in bile. |
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Authors:
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R Pakula; F M Konikoff; M Rubin; Y Ringel; Y Peled; A Tietz; T Gilat |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Lipids Volume: 31 ISSN: 0024-4201 ISO Abbreviation: Lipids Publication Date: 1996 Mar |
Date Detail:
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Created Date: 1996-12-27 Completed Date: 1996-12-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0060450 Medline TA: Lipids Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 295-303 Citation Subset: IM |
Affiliation:
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Sackler Faculty of Medicine, Tel-Aviv University, Ramat Aviv, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Bile / chemistry*, metabolism Cell Membrane / chemistry, metabolism Diet Erythrocytes / metabolism Fatty Acids / analysis, chemistry, metabolism Female Humans Male Membrane Lipids / chemistry, metabolism* Middle Aged Phosphatidylcholines / chemistry Phosphatidylethanolamines / metabolism, pharmacology Phospholipids / chemistry, metabolism, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Membrane Lipids; 0/Phosphatidylcholines; 0/Phosphatidylethanolamines; 0/Phospholipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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