| The effects of dietary fibre on C-reactive protein, an inflammation marker predicting cardiovascular disease. | |
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MedLine Citation:
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PMID: 19223918 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: C-reactive protein (CRP), a sensitive marker of inflammation, is an independent predictor of future cardiovascular disease (CVD), which is a major cause of death worldwide. In epidemiological trials, high-fibre intakes have consistently been associated with reduction in CVD risk and CRP levels. OBJECTIVE: The objective of this study was to assess the influence of dietary fibre (DF) on CRP in clinical trials. DATA SOURCES: Databases were searched from the earliest record to April 2008 and supplemented by crosschecking reference lists of relevant publications. STUDY SELECTION: Human adult intervention trials, at least 2 weeks in duration, with an increased and measurable consumption of DF were included and rated for quality. DATA SYNTHESIS: Seven clinical trials were included, and six of these reported significantly lower CRP concentrations of 25-54% with increased DF consumption with dosages ranging between 3.3-7.8 g/MJ. The seventh trial with psyllium fibre supplementation failed to lower CRP levels significantly in overweight/obese individuals. Weight loss and altered fatty acid intakes were present in most of the studies. CONCLUSIONS: In the presence of weight loss and modified saturated, monounsaturated and polyunsaturated fat intakes, significantly lower CRP concentrations (downward arrow 25-54%) are seen with increased fibre consumption (> or =3.3 g/MJ). Mechanisms are inconclusive but may involve the effect of DF on weight loss, and/or changes in the secretion, turnover or metabolism of insulin, glucose, adiponectin, interleukin-6, free fatty acids and triglycerides. Clinical studies of high- and low-fibre diets are needed to explore the potential favourable effects as observed epidemiologically, and to understand individual susceptibility to its anti-inflammatory effect and long-term cardiovascular reduction. |
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Authors:
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C J North; C S Venter; J C Jerling |
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Publication Detail:
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Type: Journal Article; Review Date: 2009-02-18 |
Journal Detail:
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Title: European journal of clinical nutrition Volume: 63 ISSN: 1476-5640 ISO Abbreviation: Eur J Clin Nutr Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-08-05 Completed Date: 2009-10-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804070 Medline TA: Eur J Clin Nutr Country: England |
Other Details:
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Languages: eng Pagination: 921-33 Citation Subset: IM |
Affiliation:
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School of Physiology, Nutrition and Consumer Sciences, North-West University, Potchefstroom, South Africa. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood C-Reactive Protein / metabolism* Clinical Trials as Topic Dietary Fats Dietary Fiber / administration & dosage, pharmacology* Humans Inflammation / blood* Weight Loss |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Dietary Fats; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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