| The effects of dietary fatty acid composition in the post-sucking period on metabolic alterations in adulthood --can ω3 PUFAs prevent adverse programming outcomes? | |
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MedLine Citation:
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PMID: 22847675 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Early life nutrition is important in the regulation of metabolism in adulthood. We studied the effects of different fatty acid composition diets on adiposity measures, glucose tolerance, and peripheral glucocorticoid metabolism in overfed neonatal rats. Rat litters were adjusted to a litter size of three (small litters, SL) or ten (normal litters, NL) on postnatal day 3 to induce over-feeding or normal-feeding, respectively. After weaning, SL and NL rats were fed a ω6 polyunsaturated fatty acid (PUFA) (14% calories as fat, soybean oil) diet or high saturated fatty acids (high fat) (31% calories as fat, lard) diet until postnatal week 16, respectively. SL rats were also divided into the third group fed a ω3 PUFA diet (14% calories as fat, fish oil). A high fat diet induced earlier and/or more pronounced weight gain, hyperphagia, glucose intolerance, and hyperlipidemia in SL rats compared to NL rats. In addition, a high fat diet increased 11β-HSD1 mRNA expression and activity in the retroperitoneal adipose tissue of both litter groups compared to standard chow counterparts, whereas high fat feeding increased hepatic 11β-HSD1 mRNA expression and activity only in SL rats. Small litter and high fat diet exhibited significant interactions in both retroperitoneal adipose tissue and hepatic 11β-HSD1 activity. Dietary ω3 PUFA offered protection against glucose intolerance and elevated glucocorticoid exposure in the retroperitoneal adipose tissue and liver of SL rats. Taken together, the results suggest dietary fatty acid composition in the post-sucking period may interact with neonatal feeding and co-determine metabolic alterations in adulthood. |
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Authors:
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Miao Hou; Chenlin Ji; Jing Wang; Yanhua Liu; Bin Sun; Mei Guo; Jonas Burén; Xiaonan Li |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-30 |
Journal Detail:
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Title: The Journal of endocrinology Volume: - ISSN: 1479-6805 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375363 Medline TA: J Endocrinol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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M Hou, Department of Children Health Care, Nanjing Children's Hospital, Nanjing Medical University, Nanjing, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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