Document Detail

The effects of dietary conjugated nonadecadienoic acid on body composition in mice.
MedLine Citation:
PMID:  11731328     Owner:  NLM     Status:  MEDLINE    
A 19-carbon conjugated diene, conjugated nonadecadienoic acid (CNA), inhibited heparin-releasable lipoprotein lipase and reduced lipid stores in 3T3-L1 adipocytes similarly to conjugated linoleic acid (CLA). When fed to growing mice (0.3% of diet) CNA reduced body fat by 81% whereas CLA reduced body fat by 25%. CLA and CNA differ in length by one carbon atom so they are unlikely to share a common metabolite to account for these observations.
Y Park; M W Pariza
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1533     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-12-03     Completed Date:  2001-12-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  171-4     Citation Subset:  IM    
Food Research Institute, Department of Food Microbiology and Toxicology, University of Wisconsin--Madison, 53706, USA.
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MeSH Terms
3T3 Cells
Adipocytes / drug effects,  metabolism
Body Composition / drug effects*
Body Weight / drug effects
Fatty Acids, Unsaturated / pharmacology*
Glycerol / metabolism
Linoleic Acid / pharmacology
Lipoprotein Lipase / antagonists & inhibitors
Molecular Weight
Triglycerides / metabolism
Reg. No./Substance:
0/Fatty Acids, Unsaturated; 0/Triglycerides; 2197-37-7/Linoleic Acid; 56-81-5/Glycerol; EC Lipase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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