Document Detail

The effects of dietary coenzyme Q on Drosophila life span.
MedLine Citation:
PMID:  14677636     Owner:  NLM     Status:  MEDLINE    
Reactive oxygen species (ROS), generated as by-products of aerobic metabolism, cause damage to proteins and cellular membranes, and are thus thought to influence senescence. Caenorhabditis elegans fed on diets lacking in ubiquinone coenzyme Q (CoQ), a coenzyme in the oxidative phosphorylation pathway, show increased longevity, possibly because of reduced ROS generation. We test the role of dietary CoQ in determining Drosophila melanogaster longevity by measuring survival and cytochrome c-oxidase activity (a proxy for aerobic metabolic performance) in flies fed wild-type yeast, CoQ-less yeast, or respiratory control (RC) yeast replete with CoQ but independently deficient in mitochondrial respiration. We find no evidence that dietary manipulation of CoQ in D. melanogaster increases life span or decreases age-dependent decline in cytochrome c oxidase activity. Instead, we find evidence that flies fed a diet of respiratory-deficient yeast (CoQ-less or RC) tend to have decreased longevity and increased rates of decline in cytochrome c-oxidase activity [corrected]
Michael R Palmer; Timothy B Sackton
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Aging cell     Volume:  2     ISSN:  1474-9718     ISO Abbreviation:  Aging Cell     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-17     Completed Date:  2004-08-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  101130839     Medline TA:  Aging Cell     Country:  England    
Other Details:
Languages:  eng     Pagination:  335-9     Citation Subset:  IM    
Department of Ecology and Evolutionary Biology, Box G-W, Brown University, Providence, RI 02912, USA.
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MeSH Terms
Drosophila melanogaster / physiology
Ubiquinone / pharmacology*
Grant Support
Reg. No./Substance:
Erratum In:
Aging Cell. 2005 Dec;4(6):339

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