Document Detail

The effects of a diet formulation with oats, soybeans, and flax on lipid profiles and uricemia in patients with AIDS and dyslipidemia.
MedLine Citation:
PMID:  24474009     Owner:  NLM     Status:  In-Data-Review    
Introduction Although the initiation of highly active antiretroviral therapy (HAART) is accompanied by an attenuation of viral load, metabolic disorders characterized by hyperglycemia, dyslipidemia, and lipodystrophy are often observed in patients under this treatment. Certain foods, such as oat bran, soy protein, and flaxseed, have been shown to improve a patient's lipid profile despite possible increases in uricemia. Thus, a bioactive compound was formulated using these foods to help patients with HIV/AIDS control metabolic disorders resulting from HAART. Methods An uncontrolled before and after study was performed. The total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, and uric acid before and after 3 months of consuming the formulation were compared in patients. The compound was formulated such that 40g (the recommended daily intake) contained approximately 10g of flaxseed, 20g of oat bran, and 10g of textured soy protein. Results The study population consisted of 139 patients, 31 of whom were included in the final analysis. There were no significant variations between the laboratory results obtained before and after consumption of the compound. Conclusions The regular consumption of the formulation together with individualized dietary guidance did not reduce lipid levels and did not contribute to an increase in uricemia in the study group. However, new studies with higher doses of the foods that compose the formulation should be encouraged to investigate whether these foods can positively influence the lipid profiles of these patients.
Rosângela Dos Santos Ferreira; Daiane Colman Cassaro; Hamilton Domingos; Elenir Rose Jardim Cury Pontes; Priscila Hiane Aiko; Júnia Elisa Carvalho de Meira
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Revista da Sociedade Brasileira de Medicina Tropical     Volume:  46     ISSN:  1678-9849     ISO Abbreviation:  Rev. Soc. Bras. Med. Trop.     Publication Date:    2013 Nov-Dec
Date Detail:
Created Date:  2014-01-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7507456     Medline TA:  Rev Soc Bras Med Trop     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  691-7     Citation Subset:  IM    
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