Document Detail


The effects of depression and use of antidepressive medicines during pregnancy on the methylation status of the IGF2 imprinted control regions in the offspring.
MedLine Citation:
PMID:  22414206     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
In utero exposures to environmental factors may result in persistent epigenetic modifications affecting normal development and susceptibility to chronic diseases in later life. We explored the relationship between exposure of the growing fetus to maternal depression or antidepressants and DNA methylation at two differentially methylated regions (DMRs) of the imprinted Insulin-like Growth Factor 2 (IGF2) gene. Aberrant DNA methylation at the IGF2 and neighboring H19 DMRs has been associated with deregulated IGF2 expression, childhood cancers and several chronic diseases during adulthood. Our study population is comprised of pregnant mothers and their newborns (n = 436), as part of the Newborn Epigenetics Study (NEST). A standardized questionnaire was completed and medical record data were abstracted to ascertain maternal depression and antidepressive drug use. DMR methylation levels in umbilical cord blood leukocytes were quantified using pyrosequencing. From the 436 newborns, laboratory data were obtained for 356 individuals at the IGF2 DMRs, and for 411 individuals at the H19 DMRs; about half of each group was African American or Caucasian. While overall no association between depression and methylation profiles was found, we observed a significant hypermethylation of the H19 DMRs in newborns of African American (n = 177) but not Caucasian (n = 168) mothers who reported the use of antidepressive drugs during pregnancy (β = +6.89, p = 0.01). Of note, our data reveal a race-independent association between smoking during pregnancy and methylation at the IGF2 DMR (+3.05%, p = 0.01). In conclusion, our findings suggest a race-dependent response related to maternal use of antidepressants at one of the IGF2 DMRs in the offspring.
Authors:
A Soubry; Sk Murphy; Z Huang; A Murtha; Jm Schildkraut; Rl Jirtle; F Wang; J Kurtzberg; W Demark-Wahnefried; Mr Forman; C Hoyo
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Publication Detail:
Type:  Journal Article     Date:  2011-10-26
Journal Detail:
Title:  Clinical epigenetics     Volume:  3     ISSN:  1868-7083     ISO Abbreviation:  Clin Epigenetics     Publication Date:  2011  
Date Detail:
Created Date:  2012-03-14     Completed Date:  2012-10-02     Revised Date:  2014-04-11    
Medline Journal Info:
Nlm Unique ID:  101516977     Medline TA:  Clin Epigenetics     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  2     Citation Subset:  -    
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Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R01 DK085173/DK/NIDDK NIH HHS; R01 ES016772/ES/NIEHS NIH HHS; R21 ES014947/ES/NIEHS NIH HHS; R25 CA126938/CA/NCI NIH HHS

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