| The effects of (-)-delta9-tetrahydrocannabinol on reserpine-induced hypothermia in rats. | |
| | |
MedLine Citation:
|
PMID: 4793331 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
1. An intravenous injection into rats of 1 mg/kg (-)-Delta(9)-tetrahydrocannabinol Delta(9)-THC) had no effect on rectal temperature and produced in the subcellular fractions of the brain a shift of 5-hydroxytryptamine (5-HT) from the particulate or ;bound' 5-HT to the supernatant or ;free' fraction, whereas the noradrenaline (NA) decreased in both fractions.2. Pretreatment of rats by an intravenous injection of 1 mg/kg Delta(9)-THC three times a week for four weeks, prevented the hypothermia and the reduction in brain 5-HT produced by an intraperitoneal injection of 15 mg/kg reserpine given 24 h after the last Delta(9)-THC injection.3. Pretreatment of rats by a single intravenous injection of 1 mg/kg Delta(9)-THC prevented the hypothermia and reduction in brain 5-HT produced by an intraperitoneal injection of reserpine given 1 h before. The reduction in brain NA was not prevented except at the 18 h time interval.4. An injection of 1 mg/kg Delta(9)-THC intravenously into rats 3 h after an intraperitoneal injection of reserpine accentuated the reserpine hypothermia as well as the reduction of 5-HT but not of NA in the brain.5. The reserpine hypothermia was not prevented by a single intravenous injection of 1 mg/kg Delta(9)-THC when cinanserin, a 5-HT inhibitor, was injected 30 min before the reserpine. |
| | |
Authors:
|
L F Englert; B T Ho; D Taylor |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: British journal of pharmacology Volume: 49 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 1973 Oct |
Date Detail:
|
Created Date: 1974-09-17 Completed Date: 1974-09-17 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 243-52 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anilides
/
pharmacology Animals Body Temperature / drug effects* Body Temperature Regulation / drug effects Brain Chemistry Cannabis / pharmacology* Cinnamates / pharmacology Depression, Chemical Male Norepinephrine / analysis Rats Reserpine / antagonists & inhibitors, pharmacology* Serotonin / metabolism, secretion Serotonin Antagonists Sulfides / pharmacology Temperature Tetrahydrocannabinol / administration & dosage, pharmacology Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Anilides; 0/Cinnamates; 0/Serotonin Antagonists; 0/Sulfides; 1972-08-3/Tetrahydrocannabinol; 50-55-5/Reserpine; 50-67-9/Serotonin; 51-41-2/Norepinephrine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The syndrome of myosclerosis.
Next Document: Effects of chlorpromazine on exploration and habituation in the rat.