| The effects of d-fenfluramine on saccharin intake and preference, and on food and water intake. | |
| | |
MedLine Citation:
|
PMID: 3413195 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effects of d-fenfluramine on saccharin intake and preference were examined to investigate whether the reduced rate of eating induced by this compound reflects a reduction in the palatability of foods. In two separate experiments, water deprived rats were offered a choice between a 0.05% solution of saccharin and water, or a 0.2% saccharin solution and water. Injection of d-fenfluramine at doses which reliably decreased food intake resulted in dose dependent reductions in total fluid intake and saccharin intake. A trend towards reduced water intake was observed also, and this together with the reduced saccharin intake resulted in no overall change in saccharin preference. In a further experiment, d-fenfluramine reduced the water intake of water deprived rats to the same extent as it reduced total fluid intake in the choice tests. Since d-fenfluramine failed to alter saccharin preference, it is unlikely that the slowed eating rate induced by this compound indicates a reduction in food palatability. Instead, it is likely that this behaviour results from a subtle motor deficit, such that fenfluramine treated animals are unable to maintain ingestion at the same rate as non-drugged animals. This explanation could account for the reduction in the consumption of non-nutritive saccharin solutions and water in water deprived animals. The relevance of this action to the anorectic effect of fenfluramine is discussed. |
| | |
Authors:
|
P J Fletcher |
Related Documents
:
|
7100065 - Effect of feed and water deprivation on organ and blood characteristics of young turkeys. 23528985 - Counterpoint: is clostridium difficile a food-borne disease? 11288135 - Expression of cytochrome p-450s and glutathione s-transferases in the rat liver during ... 9218095 - Effects of deprivation level on humans' self-control for food reinforcers. 7971775 - Fibre constituents of some foods. 15043045 - How can genetically modified foods be made publicly acceptable? |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Pharmacology, biochemistry, and behavior Volume: 29 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1988 Apr |
Date Detail:
|
Created Date: 1988-09-29 Completed Date: 1988-09-29 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 687-91 Citation Subset: IM |
Affiliation:
|
Neuropsychiatric Research Unit, University of Saskatchewan, Saskatoon, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Drinking / drug effects* Eating / drug effects* Fenfluramine / pharmacology* Food Preferences / drug effects* Isomerism Male Rats Rats, Inbred Strains Saccharin* |
| Chemical | |
Reg. No./Substance:
|
458-24-2/Fenfluramine; 81-07-2/Saccharin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Influence of increasing concentrations of ethanol on food and water intake, body weight, and wheel-r...
Next Document: Effect of ethyl alcohol on thermoregulation in mice following the induction of hypothermia or hypert...