Document Detail

The effects of cyclooxygenase inhibitors on tumor-induced anorexia in rats.
MedLine Citation:
PMID:  8422643     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Interleukin-1 (IL-1) and tumor necrosis factor (TNF) are potent induces of prostaglandin (PG) synthesis and injection of PGE, IL-1, or TNF decreases food intake in healthy animals, whereas the anorexigenic effects of injected IL-1 and TNF are blocked by inhibitors of PG synthesis. It has been hypothesized that host secretion of IL-1 and TNF contribute to tumor-induced anorexia. This study was undertaken to determine whether administration of PG inhibitors alters food intake in anorectic rats implanted with Walker 256 carcinoma. METHODS: Groups of six tumor-bearing rats were implanted with slow-release pellets containing ibuprofen, indomethacin, or acetylsalicylic acid. Food intake, tumor growth, and body temperature were monitored for 14 days and compared with control tumor-bearing animals implanted with placebo pellets. RESULTS: Tumor growth was associated with anorexia, fever, weight loss, and increased leukocyte secretion of IL-1 and TNF. Indomethacin and ibuprofen retarded tumor growth 30-40% and lowered body temperature compared with controls, but had no effect on food intake or body weight of tumor-bearing animals. CONCLUSIONS: Prostaglandins do not mediate tumor-induced anorexia.
D O McCarthy; J M Daun
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer     Volume:  71     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-02-23     Completed Date:  1993-02-23     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  486-92     Citation Subset:  AIM; IM    
University of Wisconsin-Madison, School of Nursing 53792.
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MeSH Terms
Anorexia / etiology*
Body Weight / drug effects
Carcinoma 256, Walker / pathology,  physiopathology*
Cyclooxygenase Inhibitors / pharmacology*
Eating / drug effects
Interleukin-1 / secretion
Neoplasm Transplantation
Prostaglandins / physiology
Rats, Sprague-Dawley
Tumor Necrosis Factor-alpha / secretion
Grant Support
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 0/Interleukin-1; 0/Prostaglandins; 0/Tumor Necrosis Factor-alpha

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