Document Detail

The effects of cromolyn sodium on the airway response to hyperpnea and cold air in asthma.
MedLine Citation:
PMID:  6773454     Owner:  NLM     Status:  MEDLINE    
In order to determine if cromolyn sodium provided protection against the marked bronchoconstriction that develops when the hyperpnea of exercise is combined with frigid air, we exposed a group of asymptomatic asthmatics to this stimulus, with and without pretreatment with this drug. Respiratory heat loss and retrotracheal and retrocardiac esophageal temperatures were measured during each challenge, and multiple aspects of pulmonary mechanics were recorded before commencement and after completion. The results demonstrated that, unlike anticholinergic agents, cromolyn sodium attenuates the obstructive response observed with these large thermal burdens, and does so without affecting airway cooling.
F J Breslin; E R McFadden; R H Ingram
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  122     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1980 Jul 
Date Detail:
Created Date:  1980-10-27     Completed Date:  1980-10-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  11-6     Citation Subset:  AIM; IM    
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MeSH Terms
Airway Resistance / drug effects
Asthma / physiopathology*
Body Temperature Regulation / drug effects
Cold Temperature*
Cromolyn Sodium / pharmacology*
Hyperventilation / physiopathology*
Respiration / drug effects*
Reg. No./Substance:
15826-37-6/Cromolyn Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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