Document Detail


The effects of cromolyn sodium on the airway response to hyperpnea and cold air in asthma.
MedLine Citation:
PMID:  6773454     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to determine if cromolyn sodium provided protection against the marked bronchoconstriction that develops when the hyperpnea of exercise is combined with frigid air, we exposed a group of asymptomatic asthmatics to this stimulus, with and without pretreatment with this drug. Respiratory heat loss and retrotracheal and retrocardiac esophageal temperatures were measured during each challenge, and multiple aspects of pulmonary mechanics were recorded before commencement and after completion. The results demonstrated that, unlike anticholinergic agents, cromolyn sodium attenuates the obstructive response observed with these large thermal burdens, and does so without affecting airway cooling.
Authors:
F J Breslin; E R McFadden; R H Ingram
Related Documents :
15546334 - A 10-year follow-up study of pulmonary function in symptomatic elite cross-country skie...
1465754 - Acute effect of inhaled bradykinin on tracheobronchial clearance in normal humans.
17636704 - Inhaled corticosteroids compared to placebo for prevention of exercise induced bronchoc...
2915184 - Lung mucociliary transport in asymptomatic asthma: effects of inhaled histamine.
2463534 - Heart rate monitoring in implanted pacemakers.
15076784 - Training enhances vascular relaxation after chemotherapy-induced vasoconstriction.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  122     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1980 Jul 
Date Detail:
Created Date:  1980-10-27     Completed Date:  1980-10-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  11-6     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Airway Resistance / drug effects
Asthma / physiopathology*
Body Temperature Regulation / drug effects
Cold Temperature*
Cromolyn Sodium / pharmacology*
Female
Humans
Hyperventilation / physiopathology*
Male
Respiration / drug effects*
Chemical
Reg. No./Substance:
15826-37-6/Cromolyn Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Hemagglutination antigen of Mycobacterium tuberculosis. Immunochemical characterization and concanav...
Next Document:  Pneumonitis caused by gold salt therapy: evidence for the role of cell-mediated immunity in its path...