| The effects of continuous positive airway pressure on plasma brain natriuretic peptide concentrations in patients presenting with acute cardiogenic pulmonary edema with preserved left ventricular systolic function. | |
| | |
MedLine Citation:
|
PMID: 20159397 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: It has been established that plasma brain natriuretic peptide (BNP) concentrations in patients with acute cardiogenic pulmonary edema (ACPE) increase in proportion to heart failure. OBJECTIVES: The aim of this study is to assess the effects of continuous positive airway pressure (CPAP) treatment on plasma BNP concentrations in patients presenting with ACPE with preserved left ventricular (LV) systolic function. METHODS: This was a prospective, observational single-center study in the emergency unit of Valduce Hospital. Twelve patients (group A) presenting with ACPE and preserved LV ejection fraction and 14 patients (group B) with systolic heart dysfunction (LV ejection fraction <45%) underwent CPAP (10 cm H(2)O) through a face mask and standard medical therapy. Plasma BNP concentrations were collected immediately before CPAP and 3, 6, and 24 hours after treatment. All patients underwent a morphological echocardiographic investigation shortly before CPAP. RESULTS: Three hours after admission, BNP significantly decreased in patients with ACPE and preserved LVEF (from 998 + or - 467 pg/mL to 858 + or - 420 pg/mL; P < .05), whereas in those with systolic dysfunction, BNP was higher than during baseline (from 1352 + or - 473 pg/mL to 1570 + or - 595 pg/mL; P < .05). CONCLUSIONS: The preliminary results of the present study show that CPAP, after 3 hours, lowers BNP levels in patients with ACPE and preserved LV systolic function compared with patients affected by systolic ACPE dysfunction where BNP levels do not change significantly. |
| | |
Authors:
|
Andrea Bellone; Massimiliano Etteri; Marco Vettorello; Vittorio Berruti; Carlo Maino; Massimo Mariani; Dante Clerici; Italo Nessi; Giancarlo Gini; Anna Natalizi; Pietro Brunati |
Related Documents
:
|
19858737 - Nt-procnp and cnp do not correlate in patients with chagas' disease: role for neutral e... 2578277 - The pentagastrin test in the diagnosis of the carcinoid syndrome. blockade of gastroint... 9147407 - Elevated levels of tau-protein in cerebrospinal fluid of patients with creutzfeldt-jako... 21127137 - Monocyte angiotensin converting enzyme expression may be associated with atherosclerosi... 8236167 - Changes in fibrinolytic parameters in male patients with type 2 (non-insulin-dependent)... 11125747 - Relationship between oxidative stress and apoe phenotype in alzheimer's disease. |
Publication Detail:
|
Type: Clinical Trial; Journal Article |
Journal Detail:
|
Title: The American journal of emergency medicine Volume: 28 ISSN: 1532-8171 ISO Abbreviation: Am J Emerg Med Publication Date: 2010 Feb |
Date Detail:
|
Created Date: 2010-02-17 Completed Date: 2010-03-19 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8309942 Medline TA: Am J Emerg Med Country: United States |
Other Details:
|
Languages: eng Pagination: 230-4 Citation Subset: IM |
Copyright Information:
|
Copyright 2010. Published by Elsevier Inc. |
Affiliation:
|
Emergency Unit, Ospedale Valduce, 22100 Como, Italy. andreabellone@libero.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Aged Continuous Positive Airway Pressure* Female Heart Diseases / therapy* Humans Male Natriuretic Peptide, Brain / blood* Prospective Studies Pulmonary Edema / therapy* Ventricular Function, Left |
| Chemical | |
Reg. No./Substance:
|
114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The impact of warm weather on mass event medical need: a review of the literature.
Next Document: Routine testing in patients with asymptomatic elevated blood pressure in the ED.