Document Detail


The effects of consecutive day propofol anesthesia on feline red blood cells.
MedLine Citation:
PMID:  7653043     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study investigated the potential for multiple exposures of propofol to induce oxidative injury, in the form of Heinz body production, to feline red blood cells. Anesthesia was induced in six healthy cats with propofol (6 mg/kg, intravenous [IV]) and maintained for 30 minutes with a propofol infusion (0.20 to 0.30 mg/kg/min, IV). The initial protocol was designed for each cat to receive 10 consecutive days of propofol anesthesia. All cats spontaneously breathed room air. Heart rate, respiratory rate, and indirect blood pressure were measured and recorded before and during anesthesia. Time to complete recovery after each infusion was measured and recorded. Heinz body analysis was performed before and after each day of propofol anesthesia. Based on predetermined criteria for discontinuing daily infusions, the mean number of consecutive days of propofol anesthesia was six and propofol administration did not continue beyond 7 days in any cat. Heart rate, respiratory rate, and indirect blood pressure did not change significantly during propofol anesthesia compared with awake values. Following the third consecutive day of propofol anesthesia, there was a significant increase from baseline in the mean percentage of Heinz bodies. Hemolysis was not detected in any cat. Recovery time significantly increased after the second consecutive day of propofol anesthesia compared with the first day. Five of six cats developed generalized malaise, anorexia, and diarrhea on day 5, 6, or 7, and two cats developed facial edema.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
J L Andress; T K Day; D Day
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary surgery : VS     Volume:  24     ISSN:  0161-3499     ISO Abbreviation:  Vet Surg     Publication Date:    1995 May-Jun
Date Detail:
Created Date:  1995-09-28     Completed Date:  1995-09-28     Revised Date:  2011-04-25    
Medline Journal Info:
Nlm Unique ID:  8113214     Medline TA:  Vet Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  277-82     Citation Subset:  IM    
Affiliation:
Mississippi State University, College of Veterinary Medicine, Mississippi State 39762-9825, USA.
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MeSH Terms
Descriptor/Qualifier:
Anesthesia, Intravenous / veterinary*
Animals
Cats / blood*
Drug Administration Schedule / veterinary
Erythrocytes / drug effects*
Female
Heinz Bodies / drug effects
Hemodynamics / drug effects
Infusions, Intravenous / veterinary
Male
Propofol / administration & dosage,  pharmacology*
Chemical
Reg. No./Substance:
2078-54-8/Propofol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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