Document Detail

The effects of conjugated linoleic acid supplementation on immune function in healthy volunteers.
MedLine Citation:
PMID:  15827560     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the effects of dietary supplementation using two isomeric blends of conjugated linoleic acid (CLA) on immune function in healthy human volunteers. DESIGN: Double-blind, randomised, placebo-controlled intervention trial. SUBJECTS AND INTERVENTION: A total of 55 healthy volunteers (n=20 males, n=35 females) were randomised into one of three study groups who received 3 g/day of a fatty acid blend containing a 50:50 cis-9, trans-11: trans-10, cis-12 CLA isomer blend (2 g CLA), and 80:20 cis-9, trans-11: trans-10, cis-12 (80:20) CLA isomer blend (1.76 g CLA) or linoleic acid (control, 2 g linoleic acid) for 8 weeks. RESULTS: Supplementation with the 80:20 CLA isomer blend significantly (P< or =0.05) enhanced PHA-induced lymphocyte proliferation. CLA decreased basal interleukin (IL)-2 secretion (P< or =0.01) and increased PHA-induced IL-2 and tumor necrosis factor alpha (TNF(alpha)) production (P< or =0.01). However, these effects were not solely attributable to CLA as similar results were observed with linoleic acid. CLA supplementation had no significant effect on peripheral blood mononuclear cells IL-4 production, or on serum-soluble intercellular adhesion molecule-1 (sICAM-1) or plasma prostaglandin E2 (PGE2) or leukotreine B4 (LTB4) concentrations. CONCLUSIONS: This study shows that CLA supplementation had a minimal effect on the markers of human immune function. Furthermore, supplementation with CLA had no immunological benefit compared with linoleic acid.
A P Nugent; H M Roche; E J Noone; A Long; D K Kelleher; M J Gibney
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  59     ISSN:  0954-3007     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-02     Completed Date:  2005-09-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  742-50     Citation Subset:  IM    
Molecular Nutrition, Department of Clinical Medicine, Trinity Centre for Health Sciences, St James's Hospital, Dublin, Ireland.
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MeSH Terms
Cytokines / biosynthesis*
Dietary Supplements
Double-Blind Method
Immunity, Cellular / drug effects*,  physiology
Interleukin-2 / biosynthesis
Leukocytes, Mononuclear / immunology
Linoleic Acid / administration & dosage,  chemistry,  pharmacology
Linoleic Acids, Conjugated / administration & dosage,  chemistry,  pharmacology*
Lymphocyte Activation / drug effects*
Tumor Necrosis Factor-alpha / biosynthesis
Reg. No./Substance:
0/Cytokines; 0/Interleukin-2; 0/Linoleic Acids, Conjugated; 0/Tumor Necrosis Factor-alpha; 2197-37-7/Linoleic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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