| The effects of conjugated linoleic acid supplementation on immune function in healthy volunteers. | |
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MedLine Citation:
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PMID: 15827560 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the effects of dietary supplementation using two isomeric blends of conjugated linoleic acid (CLA) on immune function in healthy human volunteers. DESIGN: Double-blind, randomised, placebo-controlled intervention trial. SUBJECTS AND INTERVENTION: A total of 55 healthy volunteers (n=20 males, n=35 females) were randomised into one of three study groups who received 3 g/day of a fatty acid blend containing a 50:50 cis-9, trans-11: trans-10, cis-12 CLA isomer blend (2 g CLA), and 80:20 cis-9, trans-11: trans-10, cis-12 (80:20) CLA isomer blend (1.76 g CLA) or linoleic acid (control, 2 g linoleic acid) for 8 weeks. RESULTS: Supplementation with the 80:20 CLA isomer blend significantly (P< or =0.05) enhanced PHA-induced lymphocyte proliferation. CLA decreased basal interleukin (IL)-2 secretion (P< or =0.01) and increased PHA-induced IL-2 and tumor necrosis factor alpha (TNF(alpha)) production (P< or =0.01). However, these effects were not solely attributable to CLA as similar results were observed with linoleic acid. CLA supplementation had no significant effect on peripheral blood mononuclear cells IL-4 production, or on serum-soluble intercellular adhesion molecule-1 (sICAM-1) or plasma prostaglandin E2 (PGE2) or leukotreine B4 (LTB4) concentrations. CONCLUSIONS: This study shows that CLA supplementation had a minimal effect on the markers of human immune function. Furthermore, supplementation with CLA had no immunological benefit compared with linoleic acid. |
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Authors:
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A P Nugent; H M Roche; E J Noone; A Long; D K Kelleher; M J Gibney |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: European journal of clinical nutrition Volume: 59 ISSN: 0954-3007 ISO Abbreviation: Eur J Clin Nutr Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-06-02 Completed Date: 2005-09-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804070 Medline TA: Eur J Clin Nutr Country: England |
Other Details:
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Languages: eng Pagination: 742-50 Citation Subset: IM |
Affiliation:
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Molecular Nutrition, Department of Clinical Medicine, Trinity Centre for Health Sciences, St James's Hospital, Dublin, Ireland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cytokines / biosynthesis* Dietary Supplements Double-Blind Method Female Humans Immunity, Cellular / drug effects*, physiology Interleukin-2 / biosynthesis Isomerism Leukocytes, Mononuclear / immunology Linoleic Acid / administration & dosage, chemistry, pharmacology Linoleic Acids, Conjugated / administration & dosage, chemistry, pharmacology* Lymphocyte Activation / drug effects* Male Tumor Necrosis Factor-alpha / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Interleukin-2; 0/Linoleic Acids, Conjugated; 0/Tumor Necrosis Factor-alpha; 2197-37-7/Linoleic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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