Document Detail


The effects of conjugated linoleic acid on human health-related outcomes.
MedLine Citation:
PMID:  15960862     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Conjugated linoleic acid (CLA) is a collective term for a mixture of positional and geometric isomers of conjugated dienoic derivatives of linoleic acid. CLA has received considerable attention as a result of animal experiments that report anti-carcinogenic, anti-atherogenic and anti-diabetic properties, and modulation of body composition and immune function. Several studies of CLA supplementation in human subjects have now been published, but in contrast to animal studies there has been marked variation between reports on the health-related outcomes. The consensus from seventeen published studies in human subjects is that CLA does not affect body weight or body composition. Some detrimental effects of the trans-10,cis-12 CLA isomer have also been reported in terms of altered blood lipid composition and impaired insulin sensitivity. Finally, CLA has only limited effects on immune functions in man. However, there have been reports of some interesting isomer-specific effects of CLA on the blood lipid profile, but not on immune function. These isomer-specific effects need further investigation. Until more is known, CLA supplementation in man should be considered with caution.
Authors:
Sabine Tricon; Graham C Burdge; Christine M Williams; Philip C Calder; Parveen Yaqoob
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Proceedings of the Nutrition Society     Volume:  64     ISSN:  0029-6651     ISO Abbreviation:  Proc Nutr Soc     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-06-17     Completed Date:  2005-09-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7505881     Medline TA:  Proc Nutr Soc     Country:  England    
Other Details:
Languages:  eng     Pagination:  171-82     Citation Subset:  IM    
Affiliation:
Hugh Sinclair Unit of Human Nutrition, School of Food Bioscienes, University of Reading, Whiteknights, UK. S.Tricon@reading.ac.uk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Body Composition
Humans
Insulin Resistance*
Linoleic Acids, Conjugated / immunology*,  metabolism*
Lipids / blood*
Obesity / metabolism*
Chemical
Reg. No./Substance:
0/Linoleic Acids, Conjugated; 0/Lipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Secretory factors from human adipose tissue and their functional role.
Next Document:  Bone turnover and nutritional status in Crohn's disease: relationship to circulating mononuclear cel...