| The effects of combined conventional treatment, oral antioxidants and essential fatty acids on sperm biology in subfertile men. | |
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MedLine Citation:
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PMID: 10991774 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated the effects of combined conventional treatment, oral antioxidants (N-acetyl-cysteine or vitamins A plus E) and essential fatty acids (FA) on sperm biology in an open prospective study including 27 infertile men. The evaluation included sperm characteristics, seminal reactive oxygen species (ROS), FA of sperm membrane phospholipids, sperm oxidized DNA (8-OH-dG), and induced acrosome reaction (AR). Treatment did not improve sperm motility and morphology, nor decrease the concentration of round cells and white blood cells in semen. Sperm concentration increased in oligozoospermic men (7.4+/-1.3 to 12.5+/-1.9 million/ml). Treatment significantly reduced ROS (mean+/-SEM) (775.3+/-372.2 to 150.3+/-105.2 x 10(3)counts/10 second) and 8-OH-dG (45.3+/-10.4 to 16. 8+/-3.3 fmol/microg DNA). Treatment increased the AR (55.1+/-2.2 to 71.6+/-2.2%), the proportion of polyunsaturated FA of the phospholipids, and sperm membrane fluidity. The overall pregnancy rate was 4.5% in 134 months. The per month pregnancy rate tended to be higher in partners of (ex)-smokers (7.15%, n=14,70 months) than in never-smokers (1.6%, n=13,64 months) (OR:4.57, 95% Cl:0.55-38.1). |
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Authors:
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F H Comhaire; A B Christophe; A A Zalata; W S Dhooge; A M Mahmoud; C E Depuydt |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 63 ISSN: 0952-3278 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 2000 Sep |
Date Detail:
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Created Date: 2000-11-13 Completed Date: 2000-12-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: SCOTLAND |
Other Details:
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Languages: eng Pagination: 159-65 Citation Subset: IM |
Copyright Information:
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Copyright 2000 Harcourt Publishers Ltd. |
Affiliation:
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Department of Internal Medicine, Section Endocrinology, University Hospital Ghent, De Pintelaan 185, B 9000 Ghent, Belgium. frank.comhaire@rug.ac.be |
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcysteine
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administration & dosage,
therapeutic use Acrosome Reaction Adult Antioxidants / administration & dosage*, therapeutic use* Cell Membrane / metabolism DNA / metabolism Fatty Acids, Essential / therapeutic use* Fatty Acids, Unsaturated / metabolism Female Free Radical Scavengers / administration & dosage, therapeutic use Humans Infertility, Male / therapy* Male Phospholipids / metabolism Pilot Projects Pregnancy Pregnancy Rate Prospective Studies Reactive Oxygen Species Smoking Sperm Count Spermatozoa / drug effects* Time Factors Vitamin A / administration & dosage, therapeutic use Vitamin E / administration & dosage, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Fatty Acids, Essential; 0/Fatty Acids, Unsaturated; 0/Free Radical Scavengers; 0/Phospholipids; 0/Reactive Oxygen Species; 11103-57-4/Vitamin A; 1406-18-4/Vitamin E; 616-91-1/Acetylcysteine; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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