| The effects of colony-stimulating factor-1 on the distribution of mononuclear phagocytes in the developing osteopetrotic mouse. | |
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MedLine Citation:
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PMID: 9573014 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Colony-stimulating factor-1 (CSF-1), the primary regulator of mononuclear phagocyte (Mphi) production, exists as either a circulating or cell surface, membrane-spanning molecule. To establish transplacental transfer of maternal CSF-1, gestational day-17 mothers were injected intravenously with 125I-mouse CSF-1 or human rCSF-1, and the 125I-cpm or human CSF-1 concentrations were measured in fetal tissue, placenta, and fetal/maternal sera. Biologically active CSF-1 crossed the placenta and peaked in fetal tissue, placenta, and serum 10 minutes after injection. The role of CSF-1 in perinatal Mphi development was examined by studying the CSF-1-deficient osteopetrotic (csfmop/csfmop) mouse. Fetal/neonatal mice, derived from matings of either +/csfmop females with csfmop/csfmop males or the reciprocal pairings, were genotyped and tissue Mphi identified and quantified. In the presence of circulating maternal CSF-1 (+/csfmop mother), Mphi development in csfmop/csfmop liver was essentially complete at birth relative to +/csfmop littermates, but significantly reduced in spleen, kidney, and lung. In the absence of circulating maternal CSF-1 (csfmop/csfmop mother), Mphi numbers at birth were reduced in csfmop/csfmop liver relative to the offspring of +/csfmop mothers, but were similar in spleen, kidney, and lung. We conclude that CSF-1 is required for the perinatal development of most Mphi in these tissues. Compensation for total absence of local CSF-1 production by circulating, maternal CSF-1 is tissue-specific and most prominent in liver, the first fetal organ perfused by placental blood. However, because some Mphi developed in the complete absence of CSF-1, other factors must also be involved in the regulation of macrophage development. |
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Authors:
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P Roth; M G Dominguez; E R Stanley |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Blood Volume: 91 ISSN: 0006-4971 ISO Abbreviation: Blood Publication Date: 1998 May |
Date Detail:
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Created Date: 1998-06-12 Completed Date: 1998-06-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 3773-83 Citation Subset: AIM; IM |
Affiliation:
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Division of Neonatology, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Fetal Blood / chemistry Fetal Diseases / blood, pathology Heterozygote Homozygote Humans Kidney / pathology Liver / pathology Lung / pathology Macrophage Colony-Stimulating Factor / analysis, deficiency, genetics, pharmacokinetics, pharmacology* Male Maternal-Fetal Exchange Mice Mice, Inbred C3H Mice, Inbred C57BL Organ Specificity Osteoclasts / pathology Osteopetrosis / blood, embryology, pathology* Phagocytes / drug effects* Placenta / metabolism Pregnancy / blood Recombinant Proteins / analysis, pharmacokinetics, pharmacology Spleen / pathology |
| Grant Support | |
ID/Acronym/Agency:
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CA32551/CA/NCI NIH HHS; P30-CA13330/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins; 81627-83-0/Macrophage Colony-Stimulating Factor |
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