Document Detail

The effects of cocaine on dietary self-selection in female rats.
MedLine Citation:
PMID:  8415945     Owner:  NLM     Status:  MEDLINE    
Cocaine was administered via an oral route to 18-h food deprived female rats for 14 consecutive days. Following administration of the drug or vehicle control each animal was presented with separate isocaloric rations of protein, fat, and carbohydrate in a dietary self-selection situation. Amounts consumed of each component were measured at 30 min, 60 min, 2 h, and 6 h following the drug treatment. The intake of all three macronutrients was suppressed by cocaine for 1 h. Between 2 and 6 h after administration, there was a compensatory increase in fat and carbohydrate, but not protein consumption. The results are discussed in terms of protein deficiency caused by cocaine in pregnant and/or lactating females being a causal factor in the deleterious effects on offspring.
A J Bane; J G McCoy; B S Stump; D D Avery
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiology & behavior     Volume:  54     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-11-16     Completed Date:  1993-11-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  509-13     Citation Subset:  IM    
Department of Psychology, Colorado State University, Fort Collins 80523.
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MeSH Terms
Body Weight / drug effects
Cocaine / pharmacology*
Dietary Carbohydrates / administration & dosage
Dietary Fats / administration & dosage
Dietary Proteins / administration & dosage
Dose-Response Relationship, Drug
Energy Intake / drug effects*
Food Preferences / drug effects*
Rats, Sprague-Dawley
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Fats; 0/Dietary Proteins; 50-36-2/Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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