Document Detail

The effects of clonidine on arterial baroreflex sensitivity and cardiopulmonary barorefex control of sympathetic nerve activity in patients with left ventricular dysfunction.
MedLine Citation:
PMID:  20969725     Owner:  NLM     Status:  In-Data-Review    
Background:  Clonidine is a potent sympatholytic drug with central neural effects. The aim of this study was to evaluate the effects of clonidine on arterial baroreflex sensitivity (BRS) and cardiopulmonary (CP) baroreflex control of muscle sympathetic nerve activity (MSNA) in patients with left ventricular (LV) dysfunction. Method:  Twenty patients were randomly assigned to either clonidine or placebo groups (10 in each group). BRS (by phenylephrine method) and CP baroreflex (by lower body negative pressure) effects on sympathetic nerve activity (circulating norepinephrine and MSNA recordings) were measured before and after a 4-week treatment period. Results:  Clonidine lowered blood pressure and heart rate. Clonidine was accompanied not only by a decrease in plasma noradrenaline (from 444 ± 196 to 260 ± 144 pg ml(-1) ) but also by a reduction in directly measured MSNA (from 47 ± 16 to 36 ± 16 bursts min(-1) ). BRS increased significantly from 3·01 ± 1·19 to 6·86 ± 2·84 ms mmHg(-1) after clonidine. When expressed as per cent change in MSNA during CP baroreceptor stimulation, CP baroreflex control of MSNA was significantly increased from 9·26 ± 8·93% to 28·83 ± 11·96% after clonidine. However, there were no significant changes in the measured variables in the control group. Conclusion:  Clonidine enhanced BRS and CP baroreflex control of MSNA while reducing baseline sympathetic activity in patients with LV dysfunction.
Fumio Yuasa; Akihiro Kawamura; Hiroshi Yokoe; Susumu Yoshida; Kousuke Murakawa; Tetsuro Sugiura; Toshiji Iwasaka
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Publication Detail:
Type:  Journal Article     Date:  2010-10-24
Journal Detail:
Title:  Clinical physiology and functional imaging     Volume:  31     ISSN:  1475-097X     ISO Abbreviation:  Clin Physiol Funct Imaging     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137604     Medline TA:  Clin Physiol Funct Imaging     Country:  England    
Other Details:
Languages:  eng     Pagination:  94-100     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Clinical Physiology and Functional Imaging © 2010 Scandinavian Society of Clinical Physiology and Nuclear Medicine.
The Second Department of Internal Medicine, Kansai Medical University, Osaka, Department of Clinical Laboratory Medicine, Kochi Medical School, Kochi, Japan.
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