| The effects of cisapride on elemental content in neonatal mouse small intestine in vivo. | |
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MedLine Citation:
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PMID: 8813569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of cisapride on elemental content of enterocytes, smooth muscle cells and lamina propria in neonatal mouse jejunum were studied using electron probe X-ray microanalysis. One hour after injection with cisapride (1.7 or 0.017 mg/kg body weight i.p.), Cl content was significantly reduced in villus base, crypt and smooth muscle cells and Na content decreased in muscle cells. No changes were observed in Na or Cl within villus tip cells. Total Ca content did not change significantly in any cell type following treatment with cisapride. These results confirm that cisapride induces net Cl- secretion in neonatal mouse jejunum. |
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Authors:
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A J Spencer; M P Osborne; J Stephen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of pharmacology Volume: 303 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1996 May |
Date Detail:
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Created Date: 1996-12-11 Completed Date: 1996-12-11 Revised Date: 2009-09-29 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 205-8 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of Birmingham, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Calcium / analysis Chlorides / analysis Cisapride Electrolytes / analysis* Gastrointestinal Motility / drug effects Intestine, Small / chemistry, drug effects*, physiology Mice Mice, Inbred BALB C Piperidines / pharmacology* Potassium / analysis Serotonin Agonists / pharmacology* Sodium / analysis |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Chlorides; 0/Electrolytes; 0/Piperidines; 0/Serotonin Agonists; 7440-09-7/Potassium; 7440-23-5/Sodium; 7440-70-2/Calcium; 81098-60-4/Cisapride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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