Document Detail

The effects of cisapride on elemental content in neonatal mouse small intestine in vivo.
MedLine Citation:
PMID:  8813569     Owner:  NLM     Status:  MEDLINE    
The effects of cisapride on elemental content of enterocytes, smooth muscle cells and lamina propria in neonatal mouse jejunum were studied using electron probe X-ray microanalysis. One hour after injection with cisapride (1.7 or 0.017 mg/kg body weight i.p.), Cl content was significantly reduced in villus base, crypt and smooth muscle cells and Na content decreased in muscle cells. No changes were observed in Na or Cl within villus tip cells. Total Ca content did not change significantly in any cell type following treatment with cisapride. These results confirm that cisapride induces net Cl- secretion in neonatal mouse jejunum.
A J Spencer; M P Osborne; J Stephen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  303     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-12-11     Completed Date:  1996-12-11     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  205-8     Citation Subset:  IM    
Department of Physiology, University of Birmingham, UK.
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MeSH Terms
Animals, Newborn
Calcium / analysis
Chlorides / analysis
Electrolytes / analysis*
Gastrointestinal Motility / drug effects
Intestine, Small / chemistry,  drug effects*,  physiology
Mice, Inbred BALB C
Piperidines / pharmacology*
Potassium / analysis
Serotonin Agonists / pharmacology*
Sodium / analysis
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Chlorides; 0/Electrolytes; 0/Piperidines; 0/Serotonin Agonists; 7440-09-7/Potassium; 7440-23-5/Sodium; 7440-70-2/Calcium; 81098-60-4/Cisapride

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