| The effects of cigarette smoking on pulmonary hemodynamics. | |
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MedLine Citation:
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PMID: 8131459 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neutrophils are delayed in transit in the pulmonary circulation during smoking which could reflect smoke-induced changes in local hemodynamics. The purpose of this study was to measure the changes in pulmonary hemodynamics during cigarette smoking in both healthy smokers and patients with COPD with and without pulmonary hypertension. In eight healthy smokers, cigarette smoking decreased the transit time of technetium-99m-labeled red blood cells, associated with an increase in cardiac output and a fall in the pulmonary blood volume index. In patients with COPD, the cardiac index also increased during smoking associated with a small increase in pulmonary arterial pressure only in those patients with pulmonary hypertension. However, pulmonary vascular resistance fell. These changes in pulmonary hemodynamics during cigarette smoking could not account for the increased neutrophil sequestration that has been observed previously in the lungs during smoking. |
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Authors:
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K M Skwarski; D Gorecka; P Sliwinski; J C Hogg; W MacNee |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chest Volume: 103 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 1993 Apr |
Date Detail:
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Created Date: 1994-04-19 Completed Date: 1994-04-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1166-72 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, City Hospital, Edinburgh, Scotland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Volume Cardiac Output Female Heart Catheterization Hemodynamics Humans Hypertension, Pulmonary / complications, physiopathology Lung Diseases, Obstructive / complications, physiopathology Male Middle Aged Pulmonary Circulation* Smoking / physiopathology* Vascular Resistance |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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