Document Detail

The effects of cigarette smoking and alcohol consumption on serum liver enzyme activities: a dose-related study in men.
MedLine Citation:
PMID:  8937584     Owner:  NLM     Status:  MEDLINE    
The separate and joint effects of cigarette smoking and alcohol consumption on serum activities of the enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) were investigated in 46,775 men attending the BUPA Health Screening Centre in London during the period 1983-1987, after allowing for differences in age, body mass index and exercise level. As expected, all showed a significant positive correlation with alcohol consumption. Cigarette smoking produced a significant increase in GGT activity in all drinking categories bar teetotallers, particularly for those smoking more than 20 cigarettes per day. There were no changes of clinical significance in AST or ALT activities with smoking. We postulate that the combined effects of alcohol and smoking on GGT activity are a result of induction of the enzyme by both alcohol and nicotine. Smoking as well as drinking habits should be taken into account when assessing the significance of an individual's enzyme activities.
T P Whitehead; D Robinson; S L Allaway
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of clinical biochemistry     Volume:  33 ( Pt 6)     ISSN:  0004-5632     ISO Abbreviation:  Ann. Clin. Biochem.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-03-11     Completed Date:  1997-03-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0324055     Medline TA:  Ann Clin Biochem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  530-5     Citation Subset:  IM    
BUPA Research and Clinical Audit, London, UK.
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MeSH Terms
Age Factors
Alanine Transaminase / blood*
Alcohol Drinking*
Aspartate Aminotransferases / blood*
Body Mass Index
Liver / enzymology*
Middle Aged
gamma-Glutamyltransferase / blood*
Reg. No./Substance:
EC; EC Aminotransferases; EC Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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