| The effects of chronic central administration of corticotropin-releasing factor on food intake, body weight, and hypothalamic-pituitary-adrenocortical hormones. | |
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MedLine Citation:
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PMID: 1849215 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of chronic central administration of corticotropin-releasing factor (CRF) on food intake, body weight, and hypothalamic-pituitary-adrenocortical hormones were investigated in rats. The infusion of ovine CRF at doses of 0.3 and 1.0 microgram/h continuously induced decrease in food intake and a suppression of body-weight gain for 7 days. The inhibition of body weight gain induced by CRF could not be accounted for solely by a decreased food intake since the suppression of body-weight gain in CRF-infused rats was significantly greater than that observed in rats which received the same amount of food as the CRF-infused rats. The content of proopiomelanocortin (POMC) -derived peptides in the anterior lobe of the pituitary as well as the plasma levels of ACTH and corticosterone (B) were significantly elevated in CRF-treated rats, and the CRF content in the hypothalamus was significantly decreased. These results suggest that chronic intracerebroventricular (icv) administration of CRF stimulates the synthesis and secretion of POMC-related peptides in the pituitary and suppresses food intake accompanied by inhibition of body weight gain. The results are similar to clinical and laboratory findings observed in patients with stress-induced anorexia. |
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Authors:
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M Hotta; T Shibasaki; N Yamauchi; H Ohno; R Benoit; N Ling; H Demura |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Life sciences Volume: 48 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1991 |
Date Detail:
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Created Date: 1991-05-03 Completed Date: 1991-05-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1483-91 Citation Subset: IM |
Affiliation:
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Department of Medicine, Tokyo Women's Medical College, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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metabolism Animals Blood Glucose / metabolism Body Weight / drug effects* Corticosterone / metabolism Corticotropin-Releasing Hormone / administration & dosage*, metabolism Energy Intake / drug effects* Hypothalamo-Hypophyseal System / drug effects*, metabolism Male Pituitary-Adrenal System / drug effects*, metabolism Pro-Opiomelanocortin / metabolism Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 50-22-6/Corticosterone; 66796-54-1/Pro-Opiomelanocortin; 9002-60-2/Adrenocorticotropic Hormone; 9015-71-8/Corticotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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