Document Detail

The effects of chronic central administration of corticotropin-releasing factor on food intake, body weight, and hypothalamic-pituitary-adrenocortical hormones.
MedLine Citation:
PMID:  1849215     Owner:  NLM     Status:  MEDLINE    
The effects of chronic central administration of corticotropin-releasing factor (CRF) on food intake, body weight, and hypothalamic-pituitary-adrenocortical hormones were investigated in rats. The infusion of ovine CRF at doses of 0.3 and 1.0 microgram/h continuously induced decrease in food intake and a suppression of body-weight gain for 7 days. The inhibition of body weight gain induced by CRF could not be accounted for solely by a decreased food intake since the suppression of body-weight gain in CRF-infused rats was significantly greater than that observed in rats which received the same amount of food as the CRF-infused rats. The content of proopiomelanocortin (POMC) -derived peptides in the anterior lobe of the pituitary as well as the plasma levels of ACTH and corticosterone (B) were significantly elevated in CRF-treated rats, and the CRF content in the hypothalamus was significantly decreased. These results suggest that chronic intracerebroventricular (icv) administration of CRF stimulates the synthesis and secretion of POMC-related peptides in the pituitary and suppresses food intake accompanied by inhibition of body weight gain. The results are similar to clinical and laboratory findings observed in patients with stress-induced anorexia.
M Hotta; T Shibasaki; N Yamauchi; H Ohno; R Benoit; N Ling; H Demura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  48     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1991  
Date Detail:
Created Date:  1991-05-03     Completed Date:  1991-05-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1483-91     Citation Subset:  IM    
Department of Medicine, Tokyo Women's Medical College, Japan.
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MeSH Terms
Adrenocorticotropic Hormone / metabolism
Blood Glucose / metabolism
Body Weight / drug effects*
Corticosterone / metabolism
Corticotropin-Releasing Hormone / administration & dosage*,  metabolism
Energy Intake / drug effects*
Hypothalamo-Hypophyseal System / drug effects*,  metabolism
Pituitary-Adrenal System / drug effects*,  metabolism
Pro-Opiomelanocortin / metabolism
Rats, Inbred Strains
Reg. No./Substance:
0/Blood Glucose; 50-22-6/Corticosterone; 66796-54-1/Pro-Opiomelanocortin; 9002-60-2/Adrenocorticotropic Hormone; 9015-71-8/Corticotropin-Releasing Hormone

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